| Journal: | Biocell |
| Database: | PERIÓDICA |
| System number: | 000330403 |
| ISSN: | 0327-9545 |
| Authors: | Chen, Cuixia1 Cui, Lingling2 Shang, Xin2 Zeng, Xianlu2 |
| Institutions: | 1China University of Petroleum, Centre for Bioengineering and Biotechnology, Qingdao. China 2Northeast Normal University, Institute of Genetics and Cytology, Changchun, Jilin. China |
| Year: | 2010 |
| Season: | Ago |
| Volumen: | 34 |
| Number: | 2 |
| Pages: | 57-63 |
| Country: | Argentina |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | L-selectin is a member of the selectin family that play an important role both in mediating the initial capture and subsequent rolling of leukocytes along the endothelial cells. Furthermore, L-selectin can function as a signal molecule. In our previous studies, we reported that L-selectin ligation could regulate CSF-1 (colony-stimulating factor-1) gene transcription, in which AP-1 acts as a crucial transcriptional factor. Here we investigated the function of the NFAT in the CSF-1 gene transcriptional events. We found that overexpression of WT NFAT induce CSF-1 gene transcription greatly in the activated Jurkat cells. Furthermore, we found that NFAT can be recruited to the nucleus after L-selectin ligation, and the nuclear NFAT interacts with the CSF-1 promoter region to regulate CSF-1 gene transcription in the L-selectin ligation activated Jurkat cells. These results indicate that nuclear NFAT can activate CSF-1 gene transcription by connecting with the CSF-1 promoter in the signaling events induced by L-selectin ligation |
| Disciplines: | Biología |
| Keyword: | Genética, Bioquímica, Transducción de señales, Transcripción génica, Factor de transcripción nuclear, L-selectina |
| Keyword: | Biology, Genetics, Biochemistry, Signal transduction, Gene transcription, Nuclear transcription factor, L-selectin |
| Full text: | Texto completo (Ver PDF) |
