Quality of life in individuals with spinocerebellar ataxia type 10: a preliminary study

Document title: Quality of life in individuals with spinocerebellar ataxia type 10: a preliminary study
Journal: Arquivos de neuro-psiquiatria
System number: 000420957
ISSN: 0004-282X
Authors: 1
Institutions: 1Universidade Federal do Parana, Hospital de Clinicas, Curitiba, Parana. Brasil
Season: Ago
Volumen: 76
Number: 8
Pages: 527-533
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Analítico, descriptivo
English abstract Spinocerebellar ataxia type 10 (SCA10) is characterized by gait ataxia, dysarthria, nystagmus, epilepsy, reduced cognitive ability and depression, which lead to functional loss and behavioral changes. These signs gradually evolve and may interfere with the physical, emotional, and social aspects of quality of life (QoL). Objective: To assess the self-perception of quality of life and its association with disease duration, severity of ataxia, balance and functional independence. Methods: This study focused on the disease duration, ataxia severity (SARA), balance (Berg Balance Scale), functionality (FIM, Lawton IADL) and QoL (SF-36 v.2) of 15 individuals with SCA10. Results: The population sample consisted of eight females and seven males, with a mean age of 43.8 (± 8.2) years, mean age of symptom onset of 33.1 (± 8.9) years and mean disease duration of 9.8 (± 11.2) years. The mean Berg Balance Scale score was 47.2 (± 12), mean SARA score (n = 14) 11.5 (± 7.3), mean Lawton IADL score 20.4 (± 1.8) and mean FIM score 120.3 (± 5.4). Individuals with SCA10 had a greater impairment of QoL in the “role-physical” domain (p = 0.04). The longer the disease duration (p = 0.02), risk of falling (p = 0.04), severity of ataxia (p = 0.00) and functional dependence in activities of daily living (p = 0.03) and instrumental activities of daily living (p = 0.00), the worse the QoL was in the “physical functioning” domain, with a decrease of 1.62 points for each year of disease duration. Conclusion: In this sample, the greatest impairment of QoL in individuals with SCA10 was observed in “physical functioning” and “physical role”
Portuguese abstract A Ataxia Espinocerebelar tipo 10 (SCA10) caracteriza-se pela ataxia da marcha, disartria, nistagmo, epilepsia, redução da capacidade cognitiva e depressão, causando perda funcional e alterações comportamentais. Esses sinais evoluem gradualmente e podem in
Disciplines: Medicina
Keyword: Neurología,
Enfermedades neurodegenerativas,
Ataxia espinocerebelar,
Calidad de vida
Keyword: Neurology,
Neurodegenerative diseases,
Spinocerebellar ataxia,
Quality of life
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