Avalilability of olfactory bulb: experience from a British Brain Bank



Document title: Avalilability of olfactory bulb: experience from a British Brain Bank
Journal: Arquivos de neuro-psiquiatria
Database: PERIÓDICA
System number: 000362266
ISSN: 0004-282X
Authors: 1
1
1
1
Institutions: 1University College London, Institute of Neurology, Londres. Reino Unido
Year:
Season: Feb
Volumen: 71
Number: 2
Pages: 110-112
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Aplicado, analítico
English abstract The olfactory bulb and tract (OB/OT) are among the earliest structures in the brain to undergo pathological changes in many neurodegenerative conditions. The availability of OB/OT samples from brain specimens in brain banks therefore assumes importance. We collected data from 5 years (2006-2010) regarding the presence or absence of OB/OT material in cases received by the Queen Square Brain Bank (QSBB) for Neurological Disorders, UCL Institute of Neurology, UK, to estimate availability of OB/OT material at the brain bank and also to look for possible associations. Of the 438 cases received, 320 had complete data regarding OB/OT and 29.4% of these had OB/OT in at least one half of the specimen. Unavailability of OB/OT was associated with larger post-mortem delays (p<0.001), suggesting that the delay might render the tissue more friable and hence lead to its loss. Brains from female donors also tended to have a higher availability in our samples
Portuguese abstract O bulbo e o trato olfatórios (OB/OT) são algumas das estruturas cerebrais mais sensíveis a neurodegeneração. A disponibilidade deste material para estudos neuropatológicos em bancos de cérebro tem, portanto, grande relevância. Coletamos dados referentes a 5 anos (2006-2010) a respeito da presença ou ausência de OB/OT no Queen Square Brain Bank (QSBB) for Neurological Disorders, parte do UCL Institute of Neurology, Reino Unido, para estimar a disponibildade deste material em um banco de cérebro, e também para estudar fatores que influenciam essa disponibilidade. Dos 438 casos recebidos, encontramos dados referentes a presença ou ausência de OB/OT em 320, dos quais 29,4% possuiam OB/OT em pelo menos um lado. A indisponibilidade de OB/OT foi associada a maior intervalo entre a morte e a autópsia(p<0.001), sugerindo que o atraso pode deixar o material mais friável, levando aperda durante a coleta. Cérebros de doadoras femininas apresentaram maior disponibilidade de OB/OT em nossa amostra
Disciplines: Medicina
Keyword: Neurología,
Cerebro,
Bulbo olfatorio,
Vía olfatoria,
Autopsia,
Enfermedad de Parkinson,
Neurodegeneración
Keyword: Medicine,
Neurology,
Brain,
Olfactory bulb,
Olfactory tract,
Autopsy,
Parkinson disease,
Neurodegeneration
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