Acute bacterial meningitis caused by Streptococcus pneumoniae resistant to the antimicrobian agents and their serotypes



Document title: Acute bacterial meningitis caused by Streptococcus pneumoniae resistant to the antimicrobian agents and their serotypes
Journal: Arquivos de neuro-psiquiatria
Database: PERIÓDICA
System number: 000338275
ISSN: 0004-282X
Authors: 1
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2
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3
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1
Institutions: 1Universidade Federal do Parana, Hospital de Clinicas, Curitiba, Parana. Brasil
2Laboratorio Central do Estado do Parana, Curitiba, Parana. Brasil
3Instituto Adolfo Lutz, Secao de Bacteriologia, Sao Paulo. Brasil
Year:
Season: Sep
Volumen: 66
Number: 3A
Pages: 509-515
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Aplicado, analítico
English abstract The main objectives of this study are to evaluate the resistance rates of Streptococcus pneumonia to penicillin G, ceftriaxone and vancomycin in patients with meningitis; to analyze possible risk factors to the antimicrobian resistance; to describe the serotypes detected and to suggest an initial empirical treatment for meningitis. The sensitiveness and serotypes of all isolated S. pneumoniae of patients with acute bacterial meningitis received by the Paraná State Central Laboratory from April 2001 to august 2002 have been evaluated. One hundred S. pneumoniae have been isolated, of which 15% were resistant to penicillin, 1% to cephalosporin and 0% to vancomycin. The serotypes most found were 14 (19%), 3 and 23F (10% each). When only the resistant serotypes were analyzed, the most prevalent was the 14 with 44%. The risk factors found in relation to the S. pneumoniae resistance were: age under one year old (p=0.01) and previous use of antibiotic (p=0.046). The resistance rates found, which were moderate to penicillin, low to cephalosporin and neutral to vancomycin, suggest the isolated use of a 3rd generation cephalosporin as an initial empirical therapy for the treatment of acute bacterial meningitis with a communitarian background
Portuguese abstract Este estudo teve como objetivo avaliar as taxas de resistência de Streptococcus pneumoniae, isolados de pacientes com meningite, à penicilina G, ceftriaxona e vancomicina; avaliar possíveis fatores de risco para resistência antimicrobiana; descrever os sorotipos encontrados e sugerir a terapêutica empírica inicial para meningite. Foram isoladas 100 amostras de S. pneumoniae, encontrando-se 15% de resistência à penicilina, 1% à cefalosporina e 0% à vancomicina. Os sorotipos mais encontrados foram 14 (19%), 3 e 23F (10% cada). Analisando-se os resistentes, o sorotipo 14 (44%) também foi o mais freqüente. Os fatores de risco para resistência de S. pneumoniae encontrados foram: idade menor que um ano (p=0,01) e o uso prévio de antibiótico (p=0,046). As taxas de resistência encontradas, moderada a penicilina, baixa para cefalosporina e nula para vancomicina, sugerem como terapêutica empírica inicial para tratamento da meningite bacteriana aguda de origem comunitária, a cefalosporina de terceira geração isoladamente
Disciplines: Medicina
Keyword: Microbiología,
Neurología,
Serotipos,
Streptococcus pneumoniae,
Neumococos,
Meningitis,
Resistencia antimicrobiana,
Líquido cefalorraquídeo,
Niños,
Factores de riesgo
Keyword: Medicine,
Microbiology,
Neurology,
Serotypes,
Streptococcus pneumoniae,
Pneumococcus,
Meningitis,
Antimicrobial resistance,
Cerebrospinal fluid,
Children,
Risk factors
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