| Journal: | Arquivos brasileiros de endocrinologia e metabologia |
| Database: | PERIÓDICA |
| System number: | 000289644 |
| ISSN: | 0004-2730 |
| Authors: | Vilar, Lucio1 Moura, Eliane1 Canadas, Viviane1 Gusmao, Amaro1 Campos, Renata1 Leal, Edmundo1 Teixeira, Luciano1 Santos, Vera1 Gomes, Barbara1 Lima, Marise1 Paiva, Renata1 Albuquerque, Jose Luciano1 Egito, Celia S1 Botelho, Carlos A1 Azevedo, Monalisa2 Casulari, Luiz Augusto1 Naves, Luciana A1 |
| Institutions: | 1Universidade Federal de Pernambuco, Hospital das Clinicas, Recife, Pernambuco. Brasil 2Hospital Universitario de Brasilia, Servico de Endocrinologia, Brasilia, Distrito Federal. Brasil |
| Year: | 2007 |
| Season: | Feb |
| Volumen: | 51 |
| Number: | 1 |
| Pages: | 86-91 |
| Country: | Brasil |
| Language: | Portugués |
| Document type: | Artículo |
| Approach: | Caso clínico, analítico |
| English abstract | Macroprolactinemia is characterized by the predominance in the serum of macroprolactin, a prolactin (PRL) with high molecular mass and low biological activity that does not need treatment. The prevalence of macroprolactinemia was evaluated in 115 consecutive patients with hyperprolactinemia. Among them, 19 (16.5%) had solely macroprolactinemia, 4 (3.5%) polycystic ovary syndrome, 7 (6.1%) acromegaly, 8 (6.9%) idiopathic hyperprolactinemia, 10 (8.6%) primary hypothyroidism, 14 (12.2%) clinically non-functioning pituitary adenomas, 20 (17.4%) drug-induced hyperprolactinemia and 33 (28.7%) prolactinomas. The diagnosis of macroprolactinemia was established by the demonstration of a PRL recovery < 30% after treatment of sera with polyethylene glycol. Among the 19 patients with isolated macroprolactinemia, 16 (84.2%) were female and 12 (63.2%) were asymptomatic, while 4 (21%) presented with oligomenorrhea and 3 (15.8%) with galactorrhea. In contrast, only 11.5% of individuals with other causes of hyperprolactinemia were asymptomatic (p< 0.001). Prolactin levels in cases of macroprolactin ranged from 45.1 to 404 ng/mL (mean 113.3 ± 94.5) but in 15 (78.9%) were < 100 ng/mL. Our findings demonstrate that macroprolactinemia is a common condition and, therefore, we suggest that it should be routinely screened in patients with hyperprolactinemia |
| Portuguese abstract | Macroprolactinemia caracteriza-se pelo predomínio no soro de uma prolactina (PRL) de alto peso molecular e baixa atividade biológica que não requer tratamento. A prevalência de macroprolactinemia foi avaliada em 115 pacientes consecutivos com hiperprolactinemia. Entre eles, 19 (16,5%) tinham exclusivamente macroprolactinemia, 4 (3,5%) síndrome dos ovários policísticos, 7 (6,1%) acromegalia, 8 (6,9%) hiperprolactinemia idiopática, 10 (8,7%) hipotiroidismo primário, 14 (12,2%) adenomas clinicamente não-funcionantes, 20 (17,4%) hiperprolactinemia farmacológica e 33 (28,7%) prolactinomas. O diagnóstico de macroprolactinemia foi estabelecido pela obtenção de uma recuperação da PRL < 30% após tratamento do soro com polietilenoglicol. Dentre os 19 pacientes com macroprolactinemia isolada, 16 (84,2%) eram mulheres e 12 (63,2%) eram assintomáticos, enquanto 4 (21%) tinham oligomenorréia e 3 (15,8%), galactorréia. Em contraste, apenas 11,5% dos indivíduos com outras causas de hiperprolactinemia eram assintomáticos (p< 0,001). Os níveis de PRL nos casos de macroprolactinemia variaram de 45,1 a 404 ng/mL (média de 113,3 ± 94,5), mas em 15 (78,9%) foram < 100 ng/mL. Nossos achados demonstram que macroprolactinemia é uma condição freqüente e, assim, sugerimos que seja rotineiramente pesquisada em pacientes com hiperprolactinemia |
| Disciplines: | Medicina |
| Keyword: | Endocrinología, Ginecología y obstetricia, Metabolismo y nutrición, Hiperprolactinemia, Macroprolactina, Prolactina |
| Keyword: | Medicine, Endocrinology, Gynecology and obstetrics, Metabolism and nutrition, Hyperprolactinemia, Macroprolactin, Prolactin |
| Full text: | Texto completo (Ver HTML) |
