| Journal: | Arquivos brasileiros de cardiologia |
| Database: | PERIÓDICA |
| System number: | 000287688 |
| ISSN: | 0066-782X |
| Authors: | Novazzi, Jose Paulo1 Pinto, Leonor do Espirito Santo de Almeida Auriemo, Caio Martinez, Tania Leme da Rocha |
| Institutions: | 1Universidade Federal de Sao Paulo, Escola Paulista de Medicina, Sao Paulo. Brasil |
| Year: | 1998 |
| Season: | Mar |
| Volumen: | 70 |
| Number: | 3 |
| Pages: | 155-158 |
| Country: | Brasil |
| Language: | Portugués |
| Document type: | Artículo |
| Approach: | Experimental, caso clínico |
| English abstract | PURPOSE: To evaluate lipid profile changes associated with cholestyramine addition in hypercholesterolemic patients with established coronary heart disease under treatment with HMG-CoA reductase inihibtors that had not achieved the ideal value of LDL-cholesterol. METHODS: Twenty patients with coronary heart disease, (12 submitted to coronary artery bypass grafts, 3 to coronary angioplasty and 5 maintened under clinical management) with mean age of 60.78 years old, who were under hypolipemic diet and were medicated with lovastatin 20mg/d or simvastatin 10mg/d, received cholestyramine, doses ranging from 8 to 16g/day during 8 weeks, aiming to reduce LDL-cholesterol to values less than 100mg/dL. RESULTS: There was a significant reduction of total cholesterol, from initial mean value of 239.52mg/dL to final mean value of 199.00mg/dL, with a mean reduction of 16.92%. The mean value of LDL-cholesterol was also reduced significantly from 172.73mg/dL to 118.26mg/dL, with a mean reduction of 31.53%. Mean triglyceridemia increased, still within the normal reference values, from 145.05mg/dL to 162.00mg/dL, and the mean difference was 11.69%. There was a significant increase of HDL-cholesterol fraction from an initial mean value of 38.00mg/dL to a final mean value of 48.21mg/dL, mean difference of 26.87%. Side effects were not frequent, and did not interfere in the duration of the study. CONCLUSION: The association of cholestyramine to HMG-CoA reductase inihibtors, both in low doses, in patients with primary hypercholesterolemia and high coronary risk is a good therapeutic option that can reach benefits on the lipid profile similar to those obtained when these drugs are used in association or separately in higher doses |
| Portuguese abstract | OBJETIVO: Avaliar as alterações obtidas no perfil lipídico de coronariopatas dislipidêmicos, após a adição de colestiramina, em pacientes tratados com inibidores da HMG-CoA redutase, e que não atingiram os valores ideais de LDL-colesterol. MÉTODOS: Vinte coronariopatas (12 submetidos à revascularização do miocárdio, 3 à angioplastia coronária e 5 mantidos sob tratamento clínico), com média de idade de 60,78 anos, que já realizavam dieta hipolipemiante e eram medicados com lovastatina 20mg/dia ou sinvastatina 10mg/dia, receberam também colestiramina na dose de 8 a 16g/dia durante 8 semanas, com o objetivo de reduzir LDL-colesterol para valores inferiores a 100mg/dl. RESULTADOS: Houve significante redução do colesterol total (valor médio inicial 239,52mg/dL e ao final 199,00mg/dL), obtendo-se um decréscimo percentual médio de 16,92%. O valor médio de LDL-colesterol também se reduziu, significantemente, de 172,73mg/dL para 118,26mg/dL, com decréscimo percentual médio de 31,53%. A trigliceridemia média aumentou, ainda dentro da faixa de referência normal, de 145,05mg/dL para 162,00mg/dL, (diferença percentual média de 11,69%). Houve significante aumento da fração HDL-colesterol de um valor médio inicial de 38,00mg/dL para um valor médio final de 48,21mg/dL (diferença média percentual 26,87%). Não houve efeitos adversos que impedissem a continuidade do tratamento. CONCLUSÃO: A associação de colestiramina a doses baixas de vastatinas em pacientes com hipercolesterolemia primária e de alto risco coronário é uma boa opção terapêutica, pode |
| Disciplines: | Medicina |
| Keyword: | Sistema cardiovascular, Terapéutica y rehabilitación, Colestiramina, Inhibidor reductasa HMG-CoA, Enfermedad coronaria, Prevención secundaria |
| Keyword: | Medicine, Cardiovascular system, Therapeutics and rehabilitation, Cholestyramine, HMG-CoA reductase inhibitor, Secondary prevention, Coronary artery disease |
| Full text: | Texto completo (Ver HTML) |
