| Journal: | Archives of clinical psychiatry |
| Database: | PERIÓDICA |
| System number: | 000419366 |
| Authors: | Pehlivan, Sacide1 Uysal, Mehmet Atilla2 Aydin, Nazan2 Nursal, Ayse Feyda3 Pehlivan, Mustafa4 Yavuzlar, Hazal5 Sever, Ulgen1 Kurnaz, Selin1 Yavuz, Fatih Kasım2 Uysal, Suna2 Aydin, Pinar Cetinay5 |
| Institutions: | 1Istanbul University, Istanbul Faculty of Medicine, Estambul. Turquía 2Yedikule Hospital for Chest Diseases and Thoracic Surgery, Department of Chest Diseases, Estambul. Turquía 3Hitit University, Faculty of Medicine, Corum. Turquía 4Gaziantep Univesity, Faculty of Medicine, Gaziantep. Turquía 5Bakirkoy Research and Training Hospital for Psychiatry, Neurology and Neurosurgery, Department of Psychiatry, Estambul. Turquía |
| Year: | 2018 |
| Season: | May-Jun |
| Volumen: | 45 |
| Number: | 3 |
| Pages: | 53-56 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Oxidative stress induced DNA damage has been assumed to contribute to the etiopathogenesis of schizophrenia (Sch). Smoking prevalence was more common in patients with Sch. The X-ray repair cross-complementation group 4 (XRCC4) gene plays an important role in the repair of DNA double-strand breaks. Objective: The purpose of this study was to investigate whether XRCC4 rs6869366 polymorphism has a relationship both in nicotine dependence (ND) and Sch+ND risk. Methods: One hundred and four patients with Sch+ND, 133 subjects with ND only and 70 healthy controls were enrolled in the study. XRCC4 rs6869366 polymorphism was analyzed using PCR-RFLP assay. Results: The frequency of XRCC4 rs6869366 GG genotype was more common in the ND and Sch+ND group than controls (p = 0.001 and p = 0.001, respectively). XRCC4 rs6869366 TT genotype was lower in both ND and Sch+ND group compared to controls (p = 0.001 and p = 0.001, respectively). Also, XRCC4 rs6869366 G allele was higher in Sch+ND group than controls (p = 0.001) while XRCC4 rs6869366 T allele was lower in ND group than healthy controls (p=0.001). XRCC4 rs6869366 GT genotype was lower in ND group than control group (p = 0.003). Discussion: These results suggested that the XRCC4 rs6869366 polymorphism G related genotype/allele was associated with susceptibility to both ND and Sch+ND in a Turkish population |
| Disciplines: | Medicina |
| Keyword: | Psiquiatría, Genética, Polimorfismo genético, Esquizofrenia, Susceptibilidad genética, Dependencia, Nicotina |
| Keyword: | Psychiatry, Genetics, Genetic polymorphism, Schizophrenia, Genetic susceptibility, Dependence, Nicotine |
| Full text: | Texto completo (Ver HTML) |
