Sex-differential effects of olanzapine vs. aripiprazole on glucose and lipid metabolism in first-episode schizophrenia
Document title: Sex-differential effects of olanzapine vs. aripiprazole on glucose and lipid metabolism in first-episode schizophrenia
Journal: Archives of clinical psychiatry
Database: PERIÓDICA
System number: 000428718
Authors: 1
2
1
1
1
Institutions: 1Jiangxi Mental Health Centre, Nanchang, Jiangxi. China
2The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi. China
Year:
Season: Mar-Abr
Volumen: 46
Number: 2
Pages: 33-39
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Analítico, descriptivo
English abstract To compare sex difference in metabolic effect of olanzapine versus aripiprazole on schizophrenia. Methods A twelve-week prospective open-label cohort study to compare four subgroups according to first-episode schizophrenia patients’ type of drug usage and sex: female aripiprazole (n = 11), male aripiprazole (n = 11), female olanzapine (n = 10), and male olanzapine (n = 11) for body mass index, fasting serum triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and fasting glucose. Results Aripiprazole may be associated with weight gain in female patients with low-baseline weight. Aripiprazole may have an adverse effect of weight and favorable effects of circulating glucose and lipid on female over male schizophrenia patients. The aripiprazole–induced changes in glucose and lipid may be independent of body fat storage, especially for female schizophrenia patients. Olanzapine may have adverse effects of weight, glucose and lipid profiles on female over male schizophrenic patients. Discussion Our findings fill the gap in knowledge and provide a sex-specific guidance to psychiatrist better tailoring treatment to individual sex-differential characteristics and a key clue to understand the sex-differential mechanism of antipsychotics-induced metabolic dysfunction
Disciplines: Medicina
Keyword: Psiquiatría,
Farmacología,
Esquizofrenia,
Olanzapina,
Aripiprazole,
Efectos metabólicos,
Diferencias sexuales
Keyword: Psychiatry,
Pharmacology,
Schizophrenia,
Olanzapine,
Aripiprazole,
Metabolic effects,
Sexual differences
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