Relationship between major depressive disorder and ACE gene I/D polymorphism in a Turkish population
Document title: Relationship between major depressive disorder and ACE gene I/D polymorphism in a Turkish population
Journal: Archives of clinical psychiatry
Database: PERIÓDICA
System number: 000402634
Authors: 1
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Institutions: 1Gaziosmanpasa University, Faculty of Medicine, Tokat. Turquía
2Giresun University, Faculty of Medicine, Giresun. Turquía
3Ahi Evran University, School of Health, Kirsehir. Turquía
Year:
Season: Mar-Abr
Volumen: 43
Number: 2
Pages: 27-30
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Aplicado, analítico
English abstract Major depressive disorder (MDD) is a complex disease and a significant health problem that is prevalent across the world. Angiotensin-converting enzyme (ACE) has an important role in renin-angiotensin system (RAS) and converts inactive angiotensin I to a potent vasopressor and aldosterone-stimulating peptide angiotensin II. Levels of ACE in plasma vary according to the insertion/deletion (I/D) polymorphism of ACE gene. Objective The aim of the current study was to examine the influence ACE gene I/D variations on the risk of MDD. Methods In the present case-control study, we analyzed ACE I/D polymorphism in 346 MDD patients and 210 healthy subjects using polymerase chain reaction technique. Results Comparing the two groups, no significant difference was observed with regard to either genotype distributions or allele frequencies of the I/D polymorphism of ACE gene. Discussion Our findings suggest that the ACE I/D polymorphism is not associated with MDD in Turkish case-control study. Further studies are still needed
Disciplines: Medicina
Keyword: Psiquiatría,
Genética,
Depresión mayor,
Enzima convertidora de angiotensina,
Polimorfismo,
Estudios de caso y control
Keyword: Medicine,
Psychiatry,
Genetics,
Major depression,
Angiotensin converting enzyme,
Polymorphism,
Case-control studies
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