| Journal: | Archives of clinical psychiatry |
| Database: | PERIÓDICA |
| System number: | 000394254 |
| Authors: | Silveira, Ana Stella de Azevedo1 Rocha, Deyvis Macarof Loureiro Vasconcelos1 Attux, Cecilia Ribeiro de Faissol1 Daltio, Claudiane Salles1 Silva, Leticia Aparecida da1 Elkis, Helio2 Kane, John Michael3 Bressan, Rodrigo Affonseca1 |
| Institutions: | 1Universidade Federal de Sao Paulo, Departamento de Psiquiatria, Sao Paulo. Brasil 2Universidade de Sao Paulo, Faculdade de Medicina, Sao Paulo. Brasil 3The Zucker Hillside Hospital, Department of Psychiatry, Nueva York. Estados Unidos de América |
| Year: | 2015 |
| Season: | Nov-Dic |
| Volumen: | 42 |
| Number: | 6 |
| Pages: | 165-170 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Estadística o encuesta |
| Approach: | Analítico |
| English abstract | Despite of its global underuse, clozapine is still the golden standard antipsychotic for patients with treatment-resistant schizophrenia (TRS). Objective To evaluate the patterns of clozapine and other antipsychotic drugs prescription in TRS in community mental health centers in São Paulo, Brazil. Methods A multiple-choice questionnaire was applied to fifteen psychiatrists at five centers inquiring about patients’ clinical condition, adherence to oral treatment and current antipsychotic treatment. History of previous and current antipsychotic treatment was collected through medical chart review. Results Out of 442 schizophrenia patients, 103 (23.3%) fulfilled the criteria for TRS. Fifty-eight patients (56.3%) were receiving polypharmacy; 30 (29.1%) were on atypical antipsychotic monotherapy, 14 (13.6%) were on typical antipsychotic monotherapy, 25 (24.3%) were taking depot antipsychotic medication and only 22 (21.4%) were receiving clozapine. Discussion: As well as in other parts of the world, many TRS patients (78.6%) receive other drugs instead of clozapine in São Paulo, the best evidence-based medication for patients with TRS. The government should make every effort to provide medical training and the equipment and logistic support to adequately serve those who could benefit from clozapine treatment at the community health centers |
| Disciplines: | Medicina |
| Keyword: | Farmacología, Psiquiatría, Esquizofrenia, Antipsicóticos, Clozapina, Resistencia a fármacos, Prescripción de medicamentos |
| Keyword: | Medicine, Pharmacology, Psychiatry, Schizophrenia, Antipsychotic agents, Clozapine, Drug resistance, Drug prescription |
| Full text: | Texto completo (Ver HTML) |
