NK Cell-Mediated Targeting of Human Ovarian Cancer and Possibilities for Immunotherapy
Título del documento: NK Cell-Mediated Targeting of Human Ovarian Cancer and Possibilities for Immunotherapy
Revista: ARBS. Annual review of biomedical sciences
Base de datos: PERIÓDICA
Número de sistema: 000350440
ISSN: 1678-4618
Autores: 1
1
1
Instituciones: 1Hospital da Mulher Professor Doutor Jose Aristodemo Pinotti, Centro de Atencao Integral a Saude da Mulher, Campinas, Sao Paulo. Brasil
Año:
Volumen: 13
Paginación: 23-29
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés A better understanding of the NK cell receptor-ligand interaction opened possibilities for new therapeutic strategies. The well known mismatch KIR/ HLA interaction is of great importance for NK cell stimulation. Lately, the interaction of the activating receptor DNAM-1 with its ligand PVR, has been highlighted in many ovarian carcinoma studies. Autologous and allogeneic NK cells, along with monoclonal antibodies, have been tested in current immunotherapies. This review presents information on NK cell receptor-ligand interactions and its possibilities for NK-based immunotherapy against ovarian cancer
Disciplinas: Medicina
Palabras clave: Ginecología y obstetricia,
Oncología,
Inmunología,
Ovarios,
Neoplasias,
Células NK,
Inmunoterapia,
Receptores celulares
Keyword: Medicine,
Gynecology and obstetrics,
Oncology,
Immunology,
Ovaries,
Neoplasms,
NK cells,
Immunotherapy,
Cell receptors
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