NK Cell-Mediated Targeting of Human Ovarian Cancer and Possibilities for Immunotherapy
Document title: NK Cell-Mediated Targeting of Human Ovarian Cancer and Possibilities for Immunotherapy
Journal: ARBS. Annual review of biomedical sciences
Database: PERIÓDICA
System number: 000350440
ISSN: 1678-4618
Authors: 1
1
1
Institutions: 1Hospital da Mulher Professor Doutor Jose Aristodemo Pinotti, Centro de Atencao Integral a Saude da Mulher, Campinas, Sao Paulo. Brasil
Year:
Volumen: 13
Pages: 23-29
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract A better understanding of the NK cell receptor-ligand interaction opened possibilities for new therapeutic strategies. The well known mismatch KIR/ HLA interaction is of great importance for NK cell stimulation. Lately, the interaction of the activating receptor DNAM-1 with its ligand PVR, has been highlighted in many ovarian carcinoma studies. Autologous and allogeneic NK cells, along with monoclonal antibodies, have been tested in current immunotherapies. This review presents information on NK cell receptor-ligand interactions and its possibilities for NK-based immunotherapy against ovarian cancer
Disciplines: Medicina
Keyword: Ginecología y obstetricia,
Oncología,
Inmunología,
Ovarios,
Neoplasias,
Células NK,
Inmunoterapia,
Receptores celulares
Keyword: Medicine,
Gynecology and obstetrics,
Oncology,
Immunology,
Ovaries,
Neoplasms,
NK cells,
Immunotherapy,
Cell receptors
Full text: Texto completo (Ver PDF)