Crosstalk between the Epidermal Growth Factor Receptor and Androgen Receptor Signaling Pathways in Prostate Cancer
Document title: Crosstalk between the Epidermal Growth Factor Receptor and Androgen Receptor Signaling Pathways in Prostate Cancer
Journal: ARBS. Annual review of biomedical sciences
Database: PERIÓDICA
System number: 000351971
ISSN: 1678-4618
Authors: 1
Institutions: 1University of North Carolina, Department of Pathology, Chapel Hill, Carolina del Norte. Estados Unidos de América
Year:
Volumen: 11
Pages: 102-102T113
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Analítico, descriptivo
English abstract Malignant cells are characterized by complex and often overlapping signaling pathways that modulate uncontrolled proliferation, leading to tumor growth and cancer progression. Prostate cancer is characterized by a dependence on androgens for growth initiation, and androgen deprivation is the standard treatment for advanced disease. Invariably, progression to castration-resistant prostate cancer (CRPC) occurs. Effective treatment options are currently limited to cytotoxic chemotherapy. In addition to androgen-mediated androgen receptor (AR) signaling in CRPC, multiple growth factor pathways are active, including the epidermal growth factor (EGF) receptor family of tyrosine kinases. Crosstalk between these two pathways has been studied in prostate cancer cell lines, xenograft tumor models, and in prostate cancer patients. This manuscript will focus on EGFR signaling, AR signaling, EGFR-AR crosstalk, and therapies targeted at these receptor-mediated regulatory pathways in CRPC
Disciplines: Biología,
Medicina
Keyword: Biología celular,
Oncología,
Cáncer,
Próstata,
Andrógenos,
Factor de crecimiento epidérmico,
Receptores celulares,
Terapia dirigida
Keyword: Biology,
Medicine,
Cell biology,
Oncology,
Cancer,
Prostate,
Androgens,
Targeted therapy,
Epidermal growth factor,
Cell receptors
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