Antitumor Properties of Ganoderma lucidum Polysaccharides and Terpenoids



Document title: Antitumor Properties of Ganoderma lucidum Polysaccharides and Terpenoids
Journal: ARBS. Annual review of biomedical sciences
Database: PERIÓDICA
System number: 000350436
ISSN: 1678-4618
Authors: 1
2
Institutions: 1Universidade Estadual Paulista "Julio de Mesquita Filho", Instituto de Biociencias, Botucatu, Sao Paulo. Brasil
Year:
Volumen: 13
Pages: 1-8
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Ganoderma lucidum is an edible medicinal mushroom with immunomodulatory and antitumor properties, which are mainly attributed to polysaccharides and triterpenes that can be isolated from mycelia, fruiting bodies and spores. G. lucidum has been used in a powdered form, as a medicinal beverage and a nutraceutical food (usually dried). In the present review we report some historical facts and the experimental evidence that polysaccharides and triterpenes obtained from this mushroom present potential antitumor activity. Direct effects on tumor cells include induction of apoptosis and interference in the cell cycle, whereas indirect effects are based on the modulation of immune response, usually impaired by cancer cells. Data indicate that G. lucidum can be used as a complementary tool for treatment of cancer patients
Disciplines: Medicina
Keyword: Farmacología,
Oncología,
Hongos,
Plantas medicinales,
Inmunomodulación,
Polisacáridos,
Triterpenos,
Antitumorales,
Ganoderma lucidum
Keyword: Medicine,
Oncology,
Pharmacology,
Fungi,
Medicinal plants,
Immunomodulation,
Polysaccharides,
Triterpenes,
Antitumoral agents,
Ganoderma lucidum
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