| Journal: | ARBS. Annual review of biomedical sciences |
| Database: | PERIÓDICA |
| System number: | 000270159 |
| ISSN: | 1678-4618 |
| Authors: | Nagata, Tetsuji1 |
| Institutions: | 1Shinshu University, Department of Anatomy and Cell Biology, Matsumoto. Japón |
| Year: | 2007 |
| Volumen: | 9 |
| Pages: | 30-36 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, analítico |
| English abstract | This mini-review reports aging changes of macromolecular synthesis in the mitochondria of mouse hepatocytes. We have observed the macromolecular synthesis, such as DNA, RNA and proteins, in the mitochondria of various mammalian cells by means of electron microscopic radioautography technique developed in our laboratory. The number of mitochondria per cell, number of labeled mitochondria per cell with 3H-thymidine, 3H-uridine and 3H-leucine, precursors for DNA, RNA and proteins, respectively, were counted and the labeling indices at various ages, from fetal to postnatal early days and several months to 1 and 2 years in senescence, were calculated, which showed variations due to aging |
| Disciplines: | Biología |
| Keyword: | Biología celular, Envejecimiento, Hepatocitos, Hígado, Radioautografía, Proteínas, ARN, Mitocondria, ADN |
| Keyword: | Biology, Cell biology, Aging, Hepatocytes, Liver, Radioautography, Proteins, RNA, DNA, Mitochondria |
| Full text: | Texto completo (Ver PDF) |
