| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000407166 |
| ISSN: | 1665-2681 |
| Authors: | Polyzos, Stergios A1 Kountouras, Jannis1 Polymerou, Vaia2 Papadimitriou, Kassiani G1 Zavos, Christos1 Katsinelos, Panagiotis1 |
| Institutions: | 1Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Macedonia. Grecia 2Biomedicine Laboratories, Atenas. Grecia |
| Year: | 2016 |
| Season: | Sep-Oct |
| Volumen: | 15 |
| Number: | 5 |
| Pages: | 705-714 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Data on newer adipokines and interleukins in patients with nonalcoholic fatty liver disease (NAFLD) are inconclusive. The primary aim of this study was the evaluation of serum vaspin, resistin, retinol-binding protein (RBP)-4, interleukin (IL)-1α and IL-6 levels in NAFLD patients compared to matched controls, and their association with disease severity. Material and methods. rial and methods. rial and methods. Twenty-nine consecutively enrolled NAFLD patients with histologically confirmed nonalcoholic simple steatosis (SS; n = 15) or steatohepatitis (NASH; n = 14) and 25 matched controls without NAFLD were recruited. Serum vaspin, resistin, RBP-4, IL-1α and IL-6 and biochemical tests were measured. Results. Results. Results. Serum vaspin levels were lower and IL-6 levels higher in NASH patients than controls, but similar between controls and SS patients, or NASH and SS patients (vaspin, controls: 728.5 ± 39.3; SS: 634.6 ± 63.7; NASH: 531.5 ± 52.0 pg/mL; p for trend 0.028; IL-6, controls: 1.5 ± 0.2; SS: 2.5 ± 0.6; NASH: 3.0 ± 0.6 pg/mL; p for trend 0.032). However, after adjustment for body mass index or waist circumference, both vaspin and IL-6 did not remain significantly different between groups. Resistin, RBP-4 and IL-1α were not statistically different between groups. None of the selected adipokines or interleukins could independently differentiate NAFLD from SS, or patients with more severe from less severe histological lesions. Conclusion. Conclusion. Conclusion. Lower circulating vaspin, but higher IL-6 levels were observed in NASH patients than controls, whereas resistin, RBP-4 and IL-1α levels were similar between groups. However, these differences did not remain robust after adjustment for body mass index or waist circumference |
| Disciplines: | Medicina |
| Keyword: | Gastroenterología, Bioquímica, Fisiopatología, Esteatohepatitis no alcohólica, Resistencia a la insulina, Adipocinas, Citocinas |
| Keyword: | Medicine, Gastroenterology, Biochemistry, Physiopathology, Non-alcoholic steatohepatitis, Insulin resistance, Adipokines, Cytokines |
| Full text: | Texto completo (Ver PDF) |
