| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000407822 |
| ISSN: | 1665-2681 |
| Authors: | Melchor Mendoza, Yazmín Karel1 Martínez Benítez, Braulio1 Mina Hawat, Aline2 Rodríguez Leal, Gustavo2 Duque, Ximena2 Moran Villota, Segundo3 |
| Institutions: | 1Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Patología, Ciudad de México. México 2Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Ciudad de México. México 3Fundación Clínica Médica Sur, Ciudad de México. México |
| Year: | 2017 |
| Season: | May-Jun |
| Volumen: | 16 |
| Number: | 3 |
| Pages: | 430-435 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | There is little information on survival rates of patients with primary biliary cholangtis (PBC) in developing countries. This is particularly true in Latin America, where the number of liver transplants performed remains extremely low for patients with advanced liver disease who fulfill criteria for liver transplantation. The goal of this study was to compare survival rate of patients with PBC in developing countries who were treated with ursodeoxycholic acid (UDCA) versus survival of patients who received other treatments (OT) without UDCA, prescribed before the UDCA era. Material and methods. Material and methods. Material and methods. A retrospective study was performed, including records of 78 patients with PBC in the liver unit in a third level referral hospital in Mexico City. Patients were followed for five years from initial diagnosis until death related to liver disease or to the end of the study. Patients received UDCA (15 mg/kg/per day) (n = 41) or OT (n = 37) before introduction of UDCA in Mexico. Results. Results. Results. Response to treatment was higher in the group that received UDCA. In the five years of follow-up, survival rates were significantly higher in the UDCA group than in the OT group. The hazard ratio of death was higher in the OT group vs. UDCA group, HR 8.78 (95% CI, 2.52-30.61); Mayo Risk Score and gender were independently associated with the risk of death. Conclusions. Conclusions. Conclusions. The study confirms that the use of UDCA in countries with a limited liver transplant program increases survival in comparison to other treatments used before the introduction of UDCA |
| Disciplines: | Medicina |
| Keyword: | Farmacología, Gastroenterología, Colangitis biliar primaria, Acido ursodeoxicólico, Tasa de sobrevivencia |
| Keyword: | Medicine, Gastroenterology, Pharmacology, Primary biliary cholangitis, Ursodeoxycholic acid, Survival rate |
| Full text: | Texto completo (Ver PDF) |
