Severe hypercholesterolemia mediated by lipoprotein X in a patient with cholestasis
Document title: Severe hypercholesterolemia mediated by lipoprotein X in a patient with cholestasis
Journal: Annals of hepatology
Database: PERIÓDICA
System number: 000413470
ISSN: 1665-2681
Authors: 1
1
Institutions: 1National Health Laboratory Service, Department of Chemical Pathology, Ciudad del Cabo. Sudáfrica
Year:
Season: Nov-Dic
Volumen: 14
Number: 6
Pages: 924-928
Country: México
Language: Inglés
Document type: Artículo
Approach: Caso clínico
English abstract Lipoprotein X (LpX) is an abnormal lipoprotein associated with cholestasis. It is a significant cause of severe hypercholesterolemia and should always be considered in patients with cholestatic liver disease. This case highlights the significance of LpX as a cause of severe hypercholesterolemia in a patient with cholestasis secondary to a granulomatous hepatitis attributed to tuberculosis. Lipoprotein agarose gel electrophoresis and gradient gel electrophoresis were performed for the detection of LpX. The liver function tests, electrolytes, lipid profile and bile acids were also determined. Anti-tuberculous therapy was initiated and the liver functions improved with normalisation of the lipid profile
Disciplines: Medicina
Keyword: Gastroenterología,
Metabolismo y nutrición,
Hipercolesterolemia,
Lipoproteína X,
Hepatitis granulomatosa,
Hiponatremia,
Colestasis
Keyword: Medicine,
Gastroenterology,
Metabolism and nutrition,
Hypercholesterolemia,
Lipoprotein X,
Granulomatous hepatitis,
Hyponatremia,
Cholestasis
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