Severe hypercholesterolemia mediated by lipoprotein X in a patient with cholestasis
Título del documento: Severe hypercholesterolemia mediated by lipoprotein X in a patient with cholestasis
Revista: Annals of hepatology
Base de datos: PERIÓDICA
Número de sistema: 000413470
ISSN: 1665-2681
Autors: 1
1
Institucions: 1National Health Laboratory Service, Department of Chemical Pathology, Ciudad del Cabo. Sudáfrica
Any:
Període: Nov-Dic
Volum: 14
Número: 6
Paginació: 924-928
País: México
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Caso clínico
Resumen en inglés Lipoprotein X (LpX) is an abnormal lipoprotein associated with cholestasis. It is a significant cause of severe hypercholesterolemia and should always be considered in patients with cholestatic liver disease. This case highlights the significance of LpX as a cause of severe hypercholesterolemia in a patient with cholestasis secondary to a granulomatous hepatitis attributed to tuberculosis. Lipoprotein agarose gel electrophoresis and gradient gel electrophoresis were performed for the detection of LpX. The liver function tests, electrolytes, lipid profile and bile acids were also determined. Anti-tuberculous therapy was initiated and the liver functions improved with normalisation of the lipid profile
Disciplines Medicina
Paraules clau: Gastroenterología,
Metabolismo y nutrición,
Hipercolesterolemia,
Lipoproteína X,
Hepatitis granulomatosa,
Hiponatremia,
Colestasis
Keyword: Medicine,
Gastroenterology,
Metabolism and nutrition,
Hypercholesterolemia,
Lipoprotein X,
Granulomatous hepatitis,
Hyponatremia,
Cholestasis
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