| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000415624 |
| ISSN: | 1665-2681 |
| Authors: | Gutiérrez Grobe, Ylse1 Gavilanes Espinar, Juan G1 Masso Rojas, Felipe A2 Sánchez Valle, Vicente1 Páez Arenas, Araceli2 Ponciano Rodríguez, Guadalupe3 Méndez Sánchez, Nahum1 Chávez Tapia, Norberto C1 Uribe, Misael1 |
| Institutions: | 1Fundación Clínica Médica Sur, Unidad de Investigación de Hígado, México, Distrito Federal. México 2Instituto Nacional de Cardiología Ignacio Chávez, Departamento de Fisiología, México, Distrito Federal. México 3Universidad Nacional Autónoma de México, Facultad de Medicina, México, Distrito Federal. México |
| Year: | 2013 |
| Season: | Nov-Dic |
| Volumen: | 12 |
| Number: | 6 |
| Pages: | 908-914 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Endothelial dysfunction has been previously described in metabolic syndrome patients. The levels of circulating endothelial progenitor cells (EPCs) inversely correlates with the incidence of cardiovascular disease. The aim of this study was to investigate the association between NAFLD, metabolic syndrome and EPC levels. Material and methods. A cross-sectional pilot study was performed at a university hospital in Mexico. Two groups of patients without previously known chronic diseases were studied and classified according to the presence of NAFLD. Anthropometric, dietary, and biochemical variables, and circulating EPC number were measured and compared between the groups. Results. Forty subjects were included and classified into two groups: patients with NAFLD (n = 20) and a control group (n = 20). The overall prevalence of insulin resistance and metabolic syndrome was 25% and 17.5%, respectively. EPC levels were found to be higher in the NAFLD group (p < 0.05) as in the patients with insulin resistance (p < 0.01) and metabolic syndrome (p < 0.01). These levels showed correlation with the severity of steatosis. Conclusions. Patients with NAFLD have increased levels of EPC, such levels are associated with the severity of NAFLD. These findings may suggest that these cells may play a role in the early natural history of NAFLD. EPC might be increased in an attempt to repair the endothelial damage resulting from metabolic alterations accompanying NAFLD. Further studies are needed to establish the dynamics of these cells in NAFLD |
| Disciplines: | Medicina |
| Keyword: | Gastroenterología, Sistema cardiovascular, Hígado graso no alcohólico, Síndrome metabólico, Disfunción endotelial, Riesgo cardiovascular, Células progenitoras endoteliales |
| Keyword: | Medicine, Cardiovascular system, Gastroenterology, Non alcoholic fatty liver, Metabolic syndrome, Endothelial dysfunction, Cardiovascular risk, Endothelial progenitor cells |
| Full text: | Texto completo (Ver PDF) |
