| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000407818 |
| ISSN: | 1665-2681 |
| Authors: | Palmer, William C1 Lee, David1 Burns, Justin1 Croome, Kristopher1 Rosser, Barry1 Patel, Tushar1 Keaveny, Andrew P1 Pungpapong, Surakit1 Satyanarayana, Raj Yataco, Maria1 Nakhleh, Raouf2 Musto, Kaitlyn R1 Canabal, Alexandra M3 Turnage, Alex K3 Hodge, David O4 Nguyen, Justin H1 Harnois, Denise M1 |
| Institutions: | 1Mayo Clinic, Department of Transplant, Jacksonville, Florida. Estados Unidos de América 2Mayo Clinic, Department of Pathology, Jacksonville, Florida. Estados Unidos de América 3Mayo Clinic, CRISP Program, Jacksonville, Florida. Estados Unidos de América 4Mayo Clinic, Department of Health Sciences Research, Jacksonville, Florida. Estados Unidos de América |
| Year: | 2017 |
| Season: | May-Jun |
| Volumen: | 16 |
| Number: | 3 |
| Pages: | 402-411 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Liver transplantation (LT) provides durable survival for hepatocellular carcinoma (HCC). However, there is continuing debate concerning the impact of wait time and acceptable tumor burden on outcomes after LT. We sought to review outcomes of LT for HCC at a single, large U.S. center, examining the influence of wait time on post-LT outcomes. Material and methods. methods. We methods. reviewed LT for HCC at Mayo Clinic in Florida from 1/1/2003 until 6/30/2014. Follow up was updated through 8/1/ 2015. Results. Results. From 2003-2014, 978 patients were referred for management of HCC. 376 patients were transplanted for presumed Results. HCC within Milan criteria, and the results of these 376 cases were analyzed. The median diagnosis to LT time was 183 days (8 - 4,337), and median transplant list wait time was 62 days (0 - 1815). There was no statistical difference in recurrence-free or overall survival for those with wait time of less than or greater than 180 days from diagnosis of HCC to LT. The most important predictor of long term survival after LT was HCC recurrence (HR: 18.61, p < 0.001). Recurrences of HCC as well as survival were predicted by factors related to tumor biology, including histopathological grade, vascular invasion, and pre-LT serum alpha-fetoprotein levels. Disease recurrence occurred in 13%. The overall 5-year patient survival was 65.8%, while the probability of 5-year recurrence-free survival was 62.2%. Conclusions. Conclusions. In Conclusions. this large, single-center experience with long-term data, factors of tumor biology, but not a longer wait time, were associated with recurrence-free and overall survival |
| Disciplines: | Medicina |
| Keyword: | Cirugía, Gastroenterología, Oncología, Carcinoma hepatocelular, Trasplante de hígado, Tiempo de espera, Carga tumoral |
| Keyword: | Medicine, Gastroenterology, Oncology, Surgery, Hepatocellular carcinoma, Liver transplantation, Waiting time, Tumor burden |
| Full text: | Texto completo (Ver PDF) |
