Interferon beta 1a-induced severe autoimmune hepatitis in patients with multiple sclerosis: report of two cases and review of the literature
Document title: Interferon beta 1a-induced severe autoimmune hepatitis in patients with multiple sclerosis: report of two cases and review of the literature
Journal: Annals of hepatology
Database: PERIÓDICA
System number: 000411387
ISSN: 1665-2681
Authors: 1
1
1
1
Institutions: 1Hospital Italiano de Buenos Aires, Buenos Aires. Argentina
Year:
Season: Mar-Abr
Volumen: 14
Number: 2
Pages: 273-280
Country: México
Language: Inglés
Document type: Artículo
Approach: Caso clínico, descriptivo
English abstract Type I interferons are potent cytokines that possess antiviral, immunomodulating and antiproliferative actions. The development of autoimmune hepatitis is a well recognized complication of treatment with alpha IFN in patients with chronic viral hepatitis. Yet, the occurrence in patients under treatment with beta IFN for other indications is controversial and its occurrence often underestimated. We report two cases of severe acute autoimmune hepatitis in two patients undergoing therapy with IFN beta 1a for multiple sclerosis who recovered under early immunosuppressive therapy
Disciplines: Medicina
Keyword: Farmacología,
Gastroenterología,
Inmunología,
Esclerosis múltiple,
Terapia inmunosupresora,
Interferón beta 1-A,
Hepatotoxicidad,
Falla hepática
Keyword: Medicine,
Gastroenterology,
Pharmacology,
Immunology,
Multiple sclerosis,
Immunosuppressive therapy,
Interferon beta 1-A,
Hepatotoxicity,
Liver failure
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