Interferon beta 1a-induced severe autoimmune hepatitis in patients with multiple sclerosis: report of two cases and review of the literature
Título del documento: Interferon beta 1a-induced severe autoimmune hepatitis in patients with multiple sclerosis: report of two cases and review of the literature
Revista: Annals of hepatology
Base de datos: PERIÓDICA
Número de sistema: 000411387
ISSN: 1665-2681
Autores: 1
1
1
1
Instituciones: 1Hospital Italiano de Buenos Aires, Buenos Aires. Argentina
Año:
Periodo: Mar-Abr
Volumen: 14
Número: 2
Paginación: 273-280
País: México
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Caso clínico, descriptivo
Resumen en inglés Type I interferons are potent cytokines that possess antiviral, immunomodulating and antiproliferative actions. The development of autoimmune hepatitis is a well recognized complication of treatment with alpha IFN in patients with chronic viral hepatitis. Yet, the occurrence in patients under treatment with beta IFN for other indications is controversial and its occurrence often underestimated. We report two cases of severe acute autoimmune hepatitis in two patients undergoing therapy with IFN beta 1a for multiple sclerosis who recovered under early immunosuppressive therapy
Disciplinas: Medicina
Palabras clave: Farmacología,
Gastroenterología,
Inmunología,
Esclerosis múltiple,
Terapia inmunosupresora,
Interferón beta 1-A,
Hepatotoxicidad,
Falla hepática
Keyword: Medicine,
Gastroenterology,
Pharmacology,
Immunology,
Multiple sclerosis,
Immunosuppressive therapy,
Interferon beta 1-A,
Hepatotoxicity,
Liver failure
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