| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000411831 |
| ISSN: | 1665-2681 |
| Authors: | Martínez Macías, Roberto F1 Cordero Pérez, Paula1 Juárez Rodríguez, Omar A1 Chen López, Carlos Y1 Martínez Carrillo, Francisco M1 Alarcón Galván, Gabriela1 Mercado Hernández, Roberto2 Muñoz Espinosa, Linda E1 |
| Institutions: | 1Universidad Autónoma de Nuevo León, Hospital Universitario Dr. José Eleuterio González, Monterrey, Nuevo León. México 2Universidad Autónoma de Nuevo León, Facultad de Ciencias Biológicas, Monterrey, Nuevo León. México |
| Year: | 2015 |
| Season: | Ene-Feb |
| Volumen: | 14 |
| Number: | 1 |
| Pages: | 36-45 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | We compared mortality and complications of chronic hepatitis C between treated and untreated Mexican patients after long-term follow-up. We used a time-to-event analysis and identified the prognostic factors. Material and methods. Seventy-four patients with chronic hepatitis C were studied. They were ≥ 18 years of age and had a molecular diagnosis of chronic hepatitis C and ≥ 6 months of follow-up. Patients with neoplasia or those infected with human immunodeficiency virus or hepatitis B Virus were excluded. Kaplan-Meier analysis, log-rank test, annualized incidence per 100 person-years, and stepwise discriminant analysis were used to analyse mortality and complications. Results. The end-point of annualized incidence was lowest in sustained virological responders, intermediate in non-responders, and highest in untreated patients. The absence of treatment impacted adversely on cirrhosis development and the occurrence of portal hypertension and hepatic decompensation/hepatocellular carcinoma (logrank, p < 0.05). Diabetes impacted adversely on liver-related death/liver transplantation among untreated patients. Stepwise discriminant analysis showed that diabetes, high blood pressure, and no retreatment predicted cirrhosis development (eigenvalue ≥ 0.8; p < 0.05). A MELD score ≥ 18 and age ≥ 50 years predicted hepatic decompensation/hepatocellular carcinoma (eigenvalue < 0.8; p < 0.05). APRI ≥ 1.5 predicted mortality/liver transplantation and liver-related death/liver transplantation (eigenvalue < 0.8; p < 0.05). Conclusions. This is the first long-term study of chronic hepatitis C among Mexican patients. Treated patients showed less progression of liver disease. Treated patients showed less progression of liver disease; and older patients, those with metabolic comorbidities, with MELD score ≥ 18 and APRI ≥ 1.5 exhibited adverse effects |
| Disciplines: | Medicina |
| Keyword: | Farmacología, Gastroenterología, Hepatitis crónica, Interferón, Seguimiento, Diabetes, Descompensación hepática |
| Keyword: | Medicine, Gastroenterology, Pharmacology, Chronic hepatitis, Interferon, Follow up, Diabetes, Hepatic decompensation |
| Full text: | Texto completo (Ver PDF) |
