| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000407195 |
| ISSN: | 1665-2681 |
| Authors: | Arab, Juan P1 Barrera, Francisco1 Gallego, Consuelo1 Valderas, Juan P1 Uribe, Sergio1 Tejos, Cristian1 Serrano, Cristóbal1 Huete, Alvaro1 Liberona, Jessica1 Labbé, Pilar1 Quiroga, Teresa2 Benítez, Carlos1 Irarrázaval, Pablo1 Riquelme, Arnoldo1 Arrese, Marco1 |
| Institutions: | 1Pontificia Universidad Católica de Chile, Facultad de Medicina, Santiago de Chile. Chile 2Pontificia Universidad Católica de Chile, Escuela de Ingeniería, Santiago de Chile. Chile |
| Year: | 2016 |
| Season: | Sep-Oct |
| Volumen: | 15 |
| Number: | 5 |
| Pages: | 721-728 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Background. Patients with type 2 diabetes mellitus (T2DM) are at risk for developing end-stage liver disease due to nonalcoholic steatohepatitis (NASH), the aggressive form of non-alcoholic fatty liver disease (NAFLD). Data on prevalence of advanced fibrosis among T2DM patients is scarce. Aim. To evaluate prevalence Aim. of steatosis, advanced fibrosis and cirrhosis using non-invasive methods in T2DM patients. Material and methods. Material and methods. 145 Material and methods. consecutive T2DM patients (> 55 years-old) were prospectively recruited. Presence of cirrhosis and advanced fibrosis was evaluated by magnetic resonance imaging (MRI) and NAFLD fibrosis score (NFS) respectively. Exclusion criteria included significant alcohol consumption, markers of viral hepatitis infection or other liver diseases. Results are expressed in percentage or median (interquartile range). Results. Results. Results. 52.6% of patients were women, the median age was 60 years old (57-64), mean BMI was 29.6 ± 4.7 kg/m2 and diabetes duration was 7.6 ± 6.9 years. A high prevalence of liver steatosis (63.9%), advanced fibrosis assessed by NFS (12.8%) and evidence of liver cirrhosis in MRI (6.0%) was observed. In a multivariate analysis GGT > 82 IU/L (P = 0.004) and no alcohol intake (P = 0.032) were independently associated to advanced fibrosis. Conclusion. Conclusion. A Conclusion. high frequency of undiagnosed advanced fibrosis and cirrhosis was observed in non-selected T2DM patients. Screening of these conditions may be warranted in this patient population |
| Disciplines: | Medicina |
| Keyword: | Endocrinología, Gastroenterología, Diabetes, Síndrome metabólico, Obesidad, Resistencia a la insulina, Esteatohepatitis no alcohólica, Fibrosis hepática, Mortalidad |
| Keyword: | Medicine, Endocrinology, Gastroenterology, Diabetes, Metabolic syndrome, Obesity, Insulin resistance, Non-alcoholic steatohepatitis, Hepatic fibrosis, Mortality |
| Full text: | Texto completo (Ver PDF) |
