High prevalence of undiagnosed liver cirrhosis and advanced fibrosis in type 2 diabetic patients
Título del documento: High prevalence of undiagnosed liver cirrhosis and advanced fibrosis in type 2 diabetic patients
Revista: Annals of hepatology
Base de datos: PERIÓDICA
Número de sistema: 000407195
ISSN: 1665-2681
Autors: 1
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Institucions: 1Pontificia Universidad Católica de Chile, Facultad de Medicina, Santiago de Chile. Chile
2Pontificia Universidad Católica de Chile, Escuela de Ingeniería, Santiago de Chile. Chile
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Període: Sep-Oct
Volum: 15
Número: 5
Paginació: 721-728
País: México
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés Background. Patients with type 2 diabetes mellitus (T2DM) are at risk for developing end-stage liver disease due to nonalcoholic steatohepatitis (NASH), the aggressive form of non-alcoholic fatty liver disease (NAFLD). Data on prevalence of advanced fibrosis among T2DM patients is scarce. Aim. To evaluate prevalence Aim. of steatosis, advanced fibrosis and cirrhosis using non-invasive methods in T2DM patients. Material and methods. Material and methods. 145 Material and methods. consecutive T2DM patients (> 55 years-old) were prospectively recruited. Presence of cirrhosis and advanced fibrosis was evaluated by magnetic resonance imaging (MRI) and NAFLD fibrosis score (NFS) respectively. Exclusion criteria included significant alcohol consumption, markers of viral hepatitis infection or other liver diseases. Results are expressed in percentage or median (interquartile range). Results. Results. Results. 52.6% of patients were women, the median age was 60 years old (57-64), mean BMI was 29.6 ± 4.7 kg/m2 and diabetes duration was 7.6 ± 6.9 years. A high prevalence of liver steatosis (63.9%), advanced fibrosis assessed by NFS (12.8%) and evidence of liver cirrhosis in MRI (6.0%) was observed. In a multivariate analysis GGT > 82 IU/L (P = 0.004) and no alcohol intake (P = 0.032) were independently associated to advanced fibrosis. Conclusion. Conclusion. A Conclusion. high frequency of undiagnosed advanced fibrosis and cirrhosis was observed in non-selected T2DM patients. Screening of these conditions may be warranted in this patient population
Disciplines Medicina
Paraules clau: Endocrinología,
Gastroenterología,
Diabetes,
Síndrome metabólico,
Obesidad,
Resistencia a la insulina,
Esteatohepatitis no alcohólica,
Fibrosis hepática,
Mortalidad
Keyword: Medicine,
Endocrinology,
Gastroenterology,
Diabetes,
Metabolic syndrome,
Obesity,
Insulin resistance,
Non-alcoholic steatohepatitis,
Hepatic fibrosis,
Mortality
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