| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000418495 |
| ISSN: | 1665-2681 |
| Authors: | Bahde, Ralf1 Holzen, Jens P1 Wolters, Heiner H1 Schmidt, Hartmut H.J2 Bock, C. Thomas3 Lugering, Andreas4 Spieker, Tilmann5 Senninger, Norbert1 Brockmann, Jens G1 |
| Institutions: | 1University Hospital of Muenster, Department of General and Visceral Surgery, Muenster, North Rhine-Westphalia. Alemania 2University Hospital of Muenster, Klinik und Poliklinik fur Transplantationsmedizin, Muenster, North Rhine-Westphalia. Alemania 3University Hospital of Tuebingen, Institute of Pathology, Tubingen, Baden-Wurttemburg. Alemania 4University Hospital of Muenster, Department of Medicine B, Muenster, North Rhine-Westphalia. Alemania 5University Hospital of Muenster, Gerhard-Domagk Institute of Pathology, Muenster, North Rhine-Westphalia. Alemania |
| Year: | 2011 |
| Season: | Jul-Sep |
| Volumen: | 10 |
| Number: | 3 |
| Pages: | 355-360 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Caso clínico, descriptivo |
| English abstract | The increasing demand for transplantation has led to consideration of liver grafts from donors exposed to hepatitis B virus (HBV). Six transplantations of liver grafts from hepatitis B surface antigen (HBsAg) positive donors have been reported; two recipients suffered from HBV/HDV (hepatitis Delta virus) coinfection and were followed up for 10-12 months. Here, we report a 56 months follow-up of a HBV/HDV-coinfected recipient of a HBsAg positive liver graft. Posttransplant combination prophylaxis consisted of hepatitis immunoglobulin, lamivudine and adefovir dipivoxil. HBsAg remained positive during stable posttransplant follow-up and subclinical HDV reinfection with low replication rate was detected at 1 month. Pegylated interferon therapy was introduced after documentation of histological evidence of mild chronic hepatitis, but without virological response after 48 weeks. Finally, antiviral treatment was switched to tenofovir disoproxil fumarate. More than 50 months posttransplant the recipient revealed clinical symptoms of decompensated liver cirrhosis and has been relisted for liver transplantation. In conclusion HBsAg positive liver grafts in HBsAg positive recipients with HDV coinfection may result in virological recurrence and rapid development of liver cirrhosis |
| Disciplines: | Medicina |
| Keyword: | Gastroenterología, Trasplante de hígado, Hepatitis B, Hepatitis D, Respuesta inmune, Antígenos |
| Keyword: | Gastroenterology, Liver transplantation, Hepatitis B, Hepatitis D, Immune response, Antigens |
| Full text: | Texto completo (Ver PDF) |
