Alopecia universalis after discontinuation of pegylated interferon and ribavirin combination therapy for hepatitis C: a case report
Document title: Alopecia universalis after discontinuation of pegylated interferon and ribavirin combination therapy for hepatitis C: a case report
Journal: Annals of hepatology
Database: PERIÓDICA
System number: 000415019
ISSN: 1665-2681
Authors: 1
1
2
2
3
3
1
1
Institutions: 1Policlinico Sant’Orsola Malpighi di Bologna, Dipartimento di Scienze Mediche e Chirurgiche, Bolonia, Emilia Romaña. Italia
2Policlinico Sant’Orsola Malpighi di Bologna, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Bolonia, Emilia Romaña. Italia
3Policlinico Sant’Orsola Malpighi di Bologna, Dipartimento di Medicina Interna, Bolonia, Emilia Romaña. Italia
Year:
Season: Mar-Abr
Volumen: 13
Number: 2
Pages: 293-296
Country: México
Language: Inglés
Document type: Artículo
Approach: Analítico, descriptivo
English abstract For the last decade, the combination therapy of pegylated interferon (Peg-IFN) plus ribavirin (RBV) has been considered as the standard of care treatment for chronic hepatitis C virus (HCV) infection. However, it has been associated with an increased incidence of many adverse cutaneous reactions and emergence of autoantibodies or even autoimmune diseases. We report a case of irreversible alopecia universalis (AU) with complete hair loss extended to the whole body, which started after discontinuation of Peg-IFN/RBV combination therapy for chronic HCV infection. In conclusion, this case represents an uncommon presentation of a common disease. Physicians must be aware of the potential adverse reactions of an antiviral therapy containing IFN, which might occur even after the discontinuation, and fully inform the patient at the beginning of his treatment course. We hope that interferon-free regimens will utterly supplant interferon-based therapy for most or all HCV patients avoiding the emergence of autoimmune manifestations
Disciplines: Medicina
Keyword: Farmacología,
Gastroenterología,
Hepatitis C,
Terapia antiviral,
Interferón pegilado,
Ribavirina,
Efectos laterales,
Alopecia
Keyword: Medicine,
Gastroenterology,
Pharmacology,
Hepatitis C,
Antiviral therapy,
Pegylated interferon,
Ribavirin,
Side effects,
Alopecia
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