Alopecia universalis after discontinuation of pegylated interferon and ribavirin combination therapy for hepatitis C: a case report
Título del documento: Alopecia universalis after discontinuation of pegylated interferon and ribavirin combination therapy for hepatitis C: a case report
Revista: Annals of hepatology
Base de datos: PERIÓDICA
Número de sistema: 000415019
ISSN: 1665-2681
Autores: 1
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2
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3
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Instituciones: 1Policlinico Sant’Orsola Malpighi di Bologna, Dipartimento di Scienze Mediche e Chirurgiche, Bolonia, Emilia Romaña. Italia
2Policlinico Sant’Orsola Malpighi di Bologna, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Bolonia, Emilia Romaña. Italia
3Policlinico Sant’Orsola Malpighi di Bologna, Dipartimento di Medicina Interna, Bolonia, Emilia Romaña. Italia
Año:
Periodo: Mar-Abr
Volumen: 13
Número: 2
Paginación: 293-296
País: México
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés For the last decade, the combination therapy of pegylated interferon (Peg-IFN) plus ribavirin (RBV) has been considered as the standard of care treatment for chronic hepatitis C virus (HCV) infection. However, it has been associated with an increased incidence of many adverse cutaneous reactions and emergence of autoantibodies or even autoimmune diseases. We report a case of irreversible alopecia universalis (AU) with complete hair loss extended to the whole body, which started after discontinuation of Peg-IFN/RBV combination therapy for chronic HCV infection. In conclusion, this case represents an uncommon presentation of a common disease. Physicians must be aware of the potential adverse reactions of an antiviral therapy containing IFN, which might occur even after the discontinuation, and fully inform the patient at the beginning of his treatment course. We hope that interferon-free regimens will utterly supplant interferon-based therapy for most or all HCV patients avoiding the emergence of autoimmune manifestations
Disciplinas: Medicina
Palabras clave: Farmacología,
Gastroenterología,
Hepatitis C,
Terapia antiviral,
Interferón pegilado,
Ribavirina,
Efectos laterales,
Alopecia
Keyword: Medicine,
Gastroenterology,
Pharmacology,
Hepatitis C,
Antiviral therapy,
Pegylated interferon,
Ribavirin,
Side effects,
Alopecia
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