Yerba mate (Ilex paraguariensis St. Hil.) extract inhibits hand-rolled cornhusk cigarette smoke-induced oxidative pulmonary damage
Document title: Yerba mate (Ilex paraguariensis St. Hil.) extract inhibits hand-rolled cornhusk cigarette smoke-induced oxidative pulmonary damage
Journal: Anais da Academia Brasileira de Ciencias
Database: PERIÓDICA
System number: 000436062
ISSN: 0001-3765
Authors: 1
2
1
1
1
2
3
2
3
3
Institutions: 1Universidade Regional Integrada do Alto Uruguai e das Missoes, Erechim, Rio Grande do Sul. Brasil
2Universidade do Extremo Sul Catarinense, Programa de Pos-graduacao em Ciencias da Saude, Criciuma, Santa Catarina. Brasil
3Pontificia Universidade Catolica do Parana, Programa de Pos-graduacao em Ciencias da Saude, Curitiba, Parana. Brasil
Year:
Volumen: 92
Number: 2
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract The aim of this study was to investigate the effects of yerba mate (Ilex paraguariensis St. Hil.) extract (YME) on oxidative stress parameters and pathological changes in the lungs of mice chronically exposed to hand-rolled cornhusk cigarette (HRC) smoke. Twenty-four male Swiss mice were divided into four groups exposed to the following treatments: control (ambient air), HRC, YME, and HRC plus YME. The animals were exposed to four HRCs per session, with 3 sessions/day, every day for 30 days. Twenty-four hours after the last inhalation, the mice were killed, and the left lungs were removed. The results showed that HRC contains elevated levels of tin and carbon oxide, but less arsenic, cobalt, manganese, and selenium than commercial cigarettes. YME administration reversed fibrosis, alveolar enlargement, and hemorrhage induced by HRC smoke. In addition, the YME and HRC significantly reduced the production of oxidants, oxidative damage and promoted a significant increase in total thiol. In conclusion, exposure to HRC smoke compromised pulmonary histoarchitecture by promoting structural changes and increasing oxidative stress in tissues. However, concomitant treatment with YME regulated the redox state and reduced the harmful effects of HRC smoke exposure in the lungs
Disciplines: Medicina
Keyword: Medicina experimental,
Toxicología,
Farmacología,
Tabaquismo,
Pulmones,
Estrés oxidativo,
Inflamación,
Extractos vegetales,
Actividad antioxidante,
Modelos animales,
Ratones,
Ilex paraguariensis,
Aquifoliaceae
Keyword: Experimental medicine,
Toxicology,
Pharmacology,
Smoking,
Lungs,
Oxidative stress,
Inflammation,
Plant extracts,
Antioxidant activity,
Animal models,
Mice,
Ilex paraguariensis,
Aquifoliaceae
Full text: Texto completo (Ver HTML) Texto completo (Ver PDF)