| Journal: | Anais da Academia Brasileira de Ciencias |
| Database: | PERIÓDICA |
| System number: | 000435807 |
| ISSN: | 0001-3765 |
| Authors: | Machado, Vanessa S1 Camponogara, Camila2 Oliveira, Sara M2 Baldissera, Matheus D3 Sagrillo, Michele R5 Gundel, Samanta da S4 Silva, Ana Paula T. da5 Ourique, Aline F5 Klein, Bruna6 Wagner, Roger6 Santos, Roberto C.V3 Silva, Aleksandro S. da7 |
| Institutions: | 1Universidade Federal de Santa Maria, Laboratorio de Microbiologia Oral, Santa Maria, Rio Grande do Sul. Brasil 2Universidade Federal de Santa Maria, Laboratorio de Neurotoxicologia e Psicofarmacologia, Santa Maria, Rio Grande do Sul. Brasil 3Universidade Federal de Santa Maria, Departamento de Microbiologia e Parasitologia, Santa Maria, Rio Grande do Sul. Brasil 4Centro Universitario Franciscano, Santa Maria, Rio Grande do Sul. Brasil 5Centro Universitário Franciscano, Programa em Nanociencia, Santa Maria, Rio Grande do Sul. Brasil 6Universidade Federal de Santa Maria, Programa de Pos-Graduacao em Ciencia e Tecnologia dos Alimentos, Santa Maria, Rio Grande do Sul. Brasil 7Universidade do Estado de Santa Catarina, Departamento de Ciencia Animal, Chapeco, Santa Catarina. Brasil |
| Year: | 2020 |
| Volumen: | 92 |
| Number: | 4 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Inflammatory dermatoses are prevalent worldwide, with impacts on the quality of life of patients and their families. The aim of this study was to determine the anti-inflammatory effects of Achyrocline satureioides oily extracts and nanocapsules on the skin using a mouse model of irritant contact dermatitis induced by croton oil, and a skin inflammation model induced by ultraviolet B (UVB) radiation. The mice were treated with 15 mg/ear oily extract (HG-OLAS) or nanocapsules (HG-NCAS) of A. satureioides incorporated into Carbopol® 940 hydrogels. We found that HG-OLAS and HG-NCAS formulations reduced ear edema in croton oil-induced lesions with maximum inhibitions of 54±7% and 74±3%, respectively. HG-OLAS and HG-NCAS formulations decreased ear edema induced by UVB radiation (0.5 J/cm2), with maximum inhibitions of 68±6% and 76±2% compared to the UVB radiation group, respectively. HG-OLAS and HG-NCAS modulated myeloperoxidase (MPO) activity after croton oil induction. Furthermore, croton oil and UVB radiation for 6 and 24 h, respectively, stimulated polymorphonuclear cells infiltration. The topical treatments reduced inflammatory processes, as shown by histological analysis. Together, the data suggest that topical application of A. satureioides oily extracts and nanocapsules produced antiedematogenic and anti-inflammatory effects. They constitute a compelling alternative for treatment of skin injuries |
| Disciplines: | Medicina |
| Keyword: | Dermatología, Farmacología, Lesiones cutáneas, Radiación ultravioleta, Antiinflamatorios, Aceites vegetales, Nanocápsulas, Achyrocline satureioides, Asteraceae |
| Keyword: | Dermatology, Pharmacology, Skin lesions, Ultraviolet radiation, Antiinflammatory agents, Plant oils, Nanocapsules, Achyrocline satureioides, Asteraceae |
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