| Journal: | Anais da Academia Brasileira de Ciencias |
| Database: | PERIÓDICA |
| System number: | 000419767 |
| ISSN: | 0001-3765 |
| Authors: | García Muñoz, María Jesús1 Sirvent, Ana1 Foubelo, Francisco1 Yus, Miguel1 |
| Institutions: | 1Universidad de Alicante, Facultad de Ciencias, Alicante. España |
| Year: | 2018 |
| Season: | May |
| Volumen: | 90 |
| Number: | 1 |
| Pages: | 1059-1072 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | A simple methodology for the synthesis of enynes by indium mediated diastereoselective allylation of aromatic N-tert-butanesulfinylimines bearing alkenyl groups at ortho-position with allyl bromide has been developed. The addition of the allyl indium intermediate to the chiral imine took place with excellent diastereoselectivity. Ruthenium-catalyzed ring-closing metathesis of the resulting enynes provided the expected cyclic 1,3-dienes in good to moderate yields. These chiral dienes are potential precursors of biologically and pharmacologically active morphane derivatives |
| Disciplines: | Medicina, Química |
| Keyword: | Química farmacéutica, Compuestos quirales, Síntesis química, Eninas, Alilación, Metátesis, Alcaloides |
| Keyword: | Medicinal chemistry, Chiral compounds, Chemical synthesis, Enynes, Allylation, Metathesis, Alkaloids |
| Full text: | Texto completo (Ver HTML) |
