Revista: | Anais da Academia Brasileira de Ciencias |
Base de datos: | PERIÓDICA |
Número de sistema: | 000419767 |
ISSN: | 0001-3765 |
Autores: | García Muñoz, María Jesús1 Sirvent, Ana1 Foubelo, Francisco1 Yus, Miguel1 |
Instituciones: | 1Universidad de Alicante, Facultad de Ciencias, Alicante. España |
Año: | 2018 |
Periodo: | May |
Volumen: | 90 |
Número: | 1 |
Paginación: | 1059-1072 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Experimental, aplicado |
Resumen en inglés | A simple methodology for the synthesis of enynes by indium mediated diastereoselective allylation of aromatic N-tert-butanesulfinylimines bearing alkenyl groups at ortho-position with allyl bromide has been developed. The addition of the allyl indium intermediate to the chiral imine took place with excellent diastereoselectivity. Ruthenium-catalyzed ring-closing metathesis of the resulting enynes provided the expected cyclic 1,3-dienes in good to moderate yields. These chiral dienes are potential precursors of biologically and pharmacologically active morphane derivatives |
Disciplinas: | Medicina, Química |
Palabras clave: | Química farmacéutica, Compuestos quirales, Síntesis química, Eninas, Alilación, Metátesis, Alcaloides |
Keyword: | Medicinal chemistry, Chiral compounds, Chemical synthesis, Enynes, Allylation, Metathesis, Alkaloids |
Texto completo: | Texto completo (Ver HTML) |