Relationship between the hsa miR 150-5p and FTO gene expression in white subcutaneous adipose tissue with overweight/obesity, lipid profile and glycemia
Document title: Relationship between the hsa miR 150-5p and FTO gene expression in white subcutaneous adipose tissue with overweight/obesity, lipid profile and glycemia
Journal: Anais da Academia Brasileira de Ciencias
Database: PERIÓDICA
System number: 000435794
ISSN: 0001-3765
Authors: 1
3
1
2
2
1
1
Institutions: 1Universidade de Sao Paulo, Faculdade de Medicina de Ribeirao Preto, Ribeirao Preto, Sao Paulo. Brasil
2Universidade de Sao Paulo, Escola de Educacao Fisica e Esporte de Ribeirao Preto, Ribeirao Preto, Sao Paulo. Brasil
3Weill Cornell Medicine, Nueva York. Estados Unidos de América
Year:
Volumen: 92
Number: 4
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Analítico, descriptivo
English abstract The overweight population is growing in the world, and the search for obesity-associated mechanisms is important for a better understanding of this disease. Few studies with the FTO gene and miRs show how they associate to obesity and how they can impact this disease. The aim of this study was to verify the relationship between the FTO gene and the hsa-miR-150-5p expression with overweight/obesity, lipid profile, and fast blood glucose. Men and women (18 years older or above), with body mass index ≥ 18.5 kg/m2, were enrolled in the present study and the FTO gene and hsa-miR-150-5p expression, biochemical parameters of blood and anthropometric measurements were analyzed. The results highlight that the FTO gene expression is associated to obesity (p 0.029), LDL-C (p 0.02) and fasting blood glucose (p 0.02), but not with triglycerides (p 0.69), total cholesterol (p 0.21), and HDL-C (p 0.24). The hsa-miR-150-5p is not associated to obesity (p 0.84), triglycerides (p 0.57), total cholesterol (p 0.51), HDL-C (p 0.75), LDL-C (p 0.32), and fasting blood glucose (p 0.42). The FTO gene expression is related to obesity, LDL-C and blood fasting glucose, representing a good molecular marker for obesity
Disciplines: Medicina
Keyword: Metabolismo y nutrición,
Genética,
Obesidad,
Tejido adiposo,
Regulación génica,
Perfil lipídico,
Glucemia
Keyword: Metabolism and nutrition,
Genetics,
Obesity,
Adipose tissue,
Gene regulation,
Lipid profile,
Glycemia
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