| Journal: | Anais da Academia Brasileira de Ciencias |
| Database: | PERIÓDICA |
| System number: | 000435949 |
| ISSN: | 0001-3765 |
| Authors: | Briñez Ortega, Edwin1 Almeida, Vera L. de2 Lopes, Julio C.D3 Burgos, Ana E1 |
| Institutions: | 1Universidad Nacional de Colombia, Departamento de Química, Bogotá. Colombia 2Fundacao Ezequiel Dias, Servico de Fitoquimica e Prospeccao Farmaceutica, Belo Horizonte, Minas Gerais. Brasil 3Universidade Federal de Minas Gerais, Instituto de Ciencias Exatas, Belo Horizonte, Minas Gerais. Brasil 4Universidad ECCI, Grupo de Investigación en Química Aplicada a la Sostenibilidad, Bogotá. Colombia |
| Year: | 2020 |
| Volumen: | 92 |
| Number: | 3 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Silver complexes containing 1,10-phenanthroline as a coordinated ligand have been of great interest due to their antibacterial and antifungal pharmacological properties. In this paper, we describe the synthesis of a new partial inclusion complex of bis(1,10-phenanthroline)silver(I) salicylate in β-cyclodextrin (β-CD) which was synthesized with a good yield. The compounds were characterized by FTIR, 1H, 13C NMR including 1H−1H COSY, TGA/DSC, elemental analysis (CHN), and X-ray powder diffraction. The results suggest the presence of non-covalent interactions such as hydrogen bonds, van der Waals forces, and hydrophobic interactions in the formation of the partial inclusion compound between β-CD and bis(1,10-phenanthroline)silver(I) salicylate [Ag(phen)2]salH. Additionally, an in silico prediction of 1,10-phenanthroline biological activities was carried out and the acquired data suggests several potential targets associated with the antimicrobial activity of this compound and its silver complex. Most predicted targets are related to antimicrobial virulence and resistance that are a serious threat to global public health. The inclusion compound showed a higher inhibiting growth of Candida albicans than the free complex [Ag(phen)2]salH indicating that the formation of the inclusion complex with β-CD increases the bioavailability of the antimicrobial active species [Ag(phen)2]+ of the new silver(I) compound |
| Disciplines: | Química |
| Keyword: | Química orgánica, Química farmacéutica, Complejos de plata, 1,10-fenantrolina, Ciclodextrina, Actividad antimicrobiana, Candida albicans |
| Keyword: | Organic chemistry, Medicinal chemistry, Silver complexes, 1,10-phenanthroline, Cyclodextrin, Antimicrobial activity, Candida albicans |
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