| Revista: | Anais da Academia Brasileira de Ciencias |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000436068 |
| ISSN: | 0001-3765 |
| Autores: | Molz, Patrícia1 Molz, Walter A2 Dallemole, Danieli R2 Santos, Luciana F.S3 Salvador, Mirian3 Cruz, Dennis B2 Prá, Daniel1 Franke, Silvia I.R1 |
| Instituciones: | 1Universidade de Santa Cruz do Sul, Departamento de Ciencias da Saude, Santa Cruz do Sul, Rio Grande do Sul. Brasil 2Universidade de Santa Cruz do Sul, Departamento de Ciencias da Vida, Santa Cruz do Sul, Rio Grande do Sul. Brasil 3Universidade de Caxias do Sul, Instituto Biotecnologia, Caxias do Sul, Rio Grande do Sul. Brasil |
| Año: | 2020 |
| Volumen: | 92 |
| Número: | 2 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | The high consumption of sugars is linked to the intermediate hyperglycemia and impaired glucose tolerance associated with obesity, inducing the prediabetes. However, the consequences of excessive invert sugar intake on glucose metabolism and genomic stability were poorly studied. The aim of this study was to evaluate the effects of invert sugar overload (32%) in rats, analyzing changes in obesity, glucose tolerance, pancreatic/hepatic histology and primary and permanent DNA damage. After 17 weeks, the rats became obese and had an excessive abdominal fat, as well as presented impaired glucose tolerance, caused by higher sugar caloric intake. Primary DNA damage, evaluated by the comet assay, was increased in the blood, however not in the pancreas. No protein carbonylation was seen in serum. Moreover, no increase in permanent DNA damage was seen in the bone marrow, evaluated using the micronucleus test. Some rats presented liver steatosis and that the pancreatic islets were enlarged, but not significantly. In this study, invert sugar altered the glucose metabolism and induced primary DNA damage in blood, but did not cause significant damage to the pancreas or liver, and neither changes in the levels of oxidative stress or permanent DNA damage |
| Disciplinas: | Medicina |
| Palabras clave: | Medicina experimental, Metabolismo y nutrición, Azúcares invertidos, Metabolismo de glucosa, Obesidad, Prediabetes, Daño genético, Histopatología |
| Keyword: | Experimental medicine, Metabolism and nutrition, Inverted sugars, Glucose metabolism, Obesity, Prediabetic state, Genetic damage, Histopathology |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
