Invert sugar induces glucose intolerance but does not cause injury to the pancreas nor permanent DNA damage in rats
Document title: Invert sugar induces glucose intolerance but does not cause injury to the pancreas nor permanent DNA damage in rats
Journal: Anais da Academia Brasileira de Ciencias
Database: PERIÓDICA
System number: 000436068
ISSN: 0001-3765
Authors: 1
2
2
3
3
2
1
1
Institutions: 1Universidade de Santa Cruz do Sul, Departamento de Ciencias da Saude, Santa Cruz do Sul, Rio Grande do Sul. Brasil
2Universidade de Santa Cruz do Sul, Departamento de Ciencias da Vida, Santa Cruz do Sul, Rio Grande do Sul. Brasil
3Universidade de Caxias do Sul, Instituto Biotecnologia, Caxias do Sul, Rio Grande do Sul. Brasil
Year:
Volumen: 92
Number: 2
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract The high consumption of sugars is linked to the intermediate hyperglycemia and impaired glucose tolerance associated with obesity, inducing the prediabetes. However, the consequences of excessive invert sugar intake on glucose metabolism and genomic stability were poorly studied. The aim of this study was to evaluate the effects of invert sugar overload (32%) in rats, analyzing changes in obesity, glucose tolerance, pancreatic/hepatic histology and primary and permanent DNA damage. After 17 weeks, the rats became obese and had an excessive abdominal fat, as well as presented impaired glucose tolerance, caused by higher sugar caloric intake. Primary DNA damage, evaluated by the comet assay, was increased in the blood, however not in the pancreas. No protein carbonylation was seen in serum. Moreover, no increase in permanent DNA damage was seen in the bone marrow, evaluated using the micronucleus test. Some rats presented liver steatosis and that the pancreatic islets were enlarged, but not significantly. In this study, invert sugar altered the glucose metabolism and induced primary DNA damage in blood, but did not cause significant damage to the pancreas or liver, and neither changes in the levels of oxidative stress or permanent DNA damage
Disciplines: Medicina
Keyword: Medicina experimental,
Metabolismo y nutrición,
Azúcares invertidos,
Metabolismo de glucosa,
Obesidad,
Prediabetes,
Daño genético,
Histopatología
Keyword: Experimental medicine,
Metabolism and nutrition,
Inverted sugars,
Glucose metabolism,
Obesity,
Prediabetic state,
Genetic damage,
Histopathology
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