| Journal: | Anais da Academia Brasileira de Ciencias |
| Database: | PERIÓDICA |
| System number: | 000436065 |
| ISSN: | 0001-3765 |
| Authors: | Bede, Teresa P1 Jesuz, Vanessa A2 Souza, Vanessa R2 Elias, Monique B2 Oliveira, Felipe L3 Dias, Juliana F4 Teodoro, Anderson J2 Azeredo, Vilma B1 |
| Institutions: | 1Universidade Federal Fluminense, Departamento de Nutricao e Dietetica, Niteroi, Rio de Janeiro. Brasil 2Universidade Federal do Estado de Rio de Janeiro, Departamento de Ciencia dos Alimentos, Rio de Janeiro. Brasil 3Universidade Federal do Rio de Janeiro, Instituto de Ciencias Biomedicas, Rio de Janeiro. Brasil 4Universidade Federal do Rio de Janeiro, Departamento de Nutricao Aplicada, Rio de Janeiro. Brasil |
| Year: | 2020 |
| Volumen: | 92 |
| Number: | 2 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | This work evaluated the effect of grape juice, red wine and resveratrol in liver parameters of rats submitted to high-fat diet. Experimental model was conducted with groups of adult females Rattus norvegicus: control (CG); high-fat (HG); grape juice (JG); red wine (RW) and resveratrol solution (RG). The high-fat diet significantly altered hepatocytes and Kupffer cells in all treated groups. HG group presented severe steatosis followed hepatocyte ballooning and tissue damages. JG group minimized hepatic histological lesion caused by high-fat diet and WG group also induced steatosis and inflammation in hepatocytes, similar to HG. Still, resveratrol protected the tissue against fatty liver disease by reducing fat infiltration and inflammation, indicating possible therapeutic effects on the liver. Cell cycle analysis showed that HG promoted damage to the tissue, reducing the viable cell content and increasing apoptosis, even when associated with wine consumption or isolated resveratrol. However, JG protected the liver against cell damage generated by the diet. Consumption of grape juice, even associated with a high-fat diet, represents a promising protection of the liver against cellular damage, but red wine further affects the tissue, and resveratrol alone was able to reduce damage but did not minimize cellular damage to the liver |
| Disciplines: | Medicina |
| Keyword: | Metabolismo y nutrición, Gastroenterología, Dietas altas en grasa, Función hepática, Jugo de uva, Vino tinto, Resveratrol |
| Keyword: | Metabolism and nutrition, Gastroenterology, High fat diets, Liver function, Grape juice, Red wine, Resveratrol |
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