Effect of Bauhinia holophylla treatment in Streptozotocin-induced diabetic rats



Document title: Effect of Bauhinia holophylla treatment in Streptozotocin-induced diabetic rats
Journal: Anais da Academia Brasileira de Ciencias
Database: PERIÓDICA
System number: 000418086
ISSN: 0001-3765
Authors: 1
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Institutions: 1Universidade Federal de Mato Grosso, Instituto de Ciencias Biologicas e da Saude, Barra do Garcas, Mato Grosso. Brasil
2Universidade Estadual Paulista "Julio de Mesquita Filho", Faculdade de Medicina de Botucatu, Botucatu, Sao Paulo. Brasil
Year:
Season: Mar
Volumen: 89
Number: 1
Pages: 263-272
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Bauhinia holophylla, commonly known as “cow’s hoof”, is widely used in Brazilian folk medicine for the diabetes treatment. Therefore, the aim of this study was at evaluating the aqueous extract effect of Bauhinia holophylla leaves treatment on the streptozotocin-induced diabetic rats. Diabetes was induced by Streptozotocin (40 mg/Kg) in female Wistar rats. Oral administration of aqueous extract of Bauhinia holophylla leaves was given to non-diabetic and diabetic rats at a dose of 400 mg/kg during 21 days. On day 17 of treatment, the Oral Glucose Tolerance Test was performed to determine the area under the curve. At the end of the treatment, the animals were anesthetized and blood was collected for serum biochemical parameters analysis. After treatment with Bauhinia holophylla extract, non-diabetic and diabetic rats presented no glycemic changes. On the other hand, the plant treatment decreased body weight and increased ALT and AST activities. In conclusion, the treatment with aqueous extract of B. holophylla leaves given to diabetic rats presented no hypoglycemic effect in nondiabetic animals and no antidiabetic effect in diabetic animals with the doses studied. In addition, the diabetic animals treated with the B. holophylla extract showed inconvenient effects and its indiscriminate consumption requires particular carefulness
Disciplines: Biología,
Química
Keyword: Fitoquímica,
Farmacología,
Angiospermas,
Plantas medicinales,
Diabetes,
Perfil lipídico,
Bauhinia holophylla,
Fabaceae
Keyword: Phytochemistry,
Pharmacology,
Angiosperms,
Medicinal plants,
Diabetes,
Lipid profile,
Bauhinia holophylla,
Fabaceae
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