| Revista: | Anais da Academia Brasileira de Ciencias |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000418086 |
| ISSN: | 0001-3765 |
| Autors: | Pinheiro, Marcelo S1 Rodrigues, Luhara S1 Neto, Leila S1 Moraes-Souza, Rafaianne Q1 Soares, Thaigra S1 Volpato, Gustavo T1 Americo, Madileine F1 Campos, Kleber E1 Damasceno, Debora C2 |
| Institucions: | 1Universidade Federal de Mato Grosso, Instituto de Ciencias Biologicas e da Saude, Barra do Garcas, Mato Grosso. Brasil 2Universidade Estadual Paulista "Julio de Mesquita Filho", Faculdade de Medicina de Botucatu, Botucatu, Sao Paulo. Brasil |
| Any: | 2017 |
| Període: | Mar |
| Volum: | 89 |
| Número: | 1 |
| Paginació: | 263-272 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Bauhinia holophylla, commonly known as “cow’s hoof”, is widely used in Brazilian folk medicine for the diabetes treatment. Therefore, the aim of this study was at evaluating the aqueous extract effect of Bauhinia holophylla leaves treatment on the streptozotocin-induced diabetic rats. Diabetes was induced by Streptozotocin (40 mg/Kg) in female Wistar rats. Oral administration of aqueous extract of Bauhinia holophylla leaves was given to non-diabetic and diabetic rats at a dose of 400 mg/kg during 21 days. On day 17 of treatment, the Oral Glucose Tolerance Test was performed to determine the area under the curve. At the end of the treatment, the animals were anesthetized and blood was collected for serum biochemical parameters analysis. After treatment with Bauhinia holophylla extract, non-diabetic and diabetic rats presented no glycemic changes. On the other hand, the plant treatment decreased body weight and increased ALT and AST activities. In conclusion, the treatment with aqueous extract of B. holophylla leaves given to diabetic rats presented no hypoglycemic effect in nondiabetic animals and no antidiabetic effect in diabetic animals with the doses studied. In addition, the diabetic animals treated with the B. holophylla extract showed inconvenient effects and its indiscriminate consumption requires particular carefulness |
| Disciplines | Biología, Química |
| Paraules clau: | Fitoquímica, Farmacología, Angiospermas, Plantas medicinales, Diabetes, Perfil lipídico, Bauhinia holophylla, Fabaceae |
| Keyword: | Phytochemistry, Pharmacology, Angiosperms, Medicinal plants, Diabetes, Lipid profile, Bauhinia holophylla, Fabaceae |
| Text complet: | Texto completo (Ver HTML) |
