Development of nanoparticles coated with cassava bagasse pectin (Manihot esculenta Crantz) containing β-carotene for mucoadhesive applications
Título del documento: Development of nanoparticles coated with cassava bagasse pectin (Manihot esculenta Crantz) containing β-carotene for mucoadhesive applications
Revista: Anais da Academia Brasileira de Ciencias
Base de datos: PERIÓDICA
Número de sistema: 000435796
ISSN: 0001-3765
Autores: 1
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Instituciones: 1Universidade Federal de Santa Catarina, Laboratorio de Morfogenese e Bioquimica Vegetal, Florianopolis, Santa Catarina. Brasil
2Universidade Federal de Santa Catarina, Laboratorio de Virologia Aplicada, Florianopolis, Santa Catarina. Brasil
3Empresa de Pesquisa Agropecuaria e Extensao Rural de Santa Catarina, Estacao Experimental de Urussanga, Urussanga, Santa Catarina. Brasil
Año:
Volumen: 92
Número: 4
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Aplicado, descriptivo
Resumen en inglés Pectin (PC) extracted from a solid residue from cassava roots (Manihot esculenta Crantz) was used to coat nanoparticles (NP) containing β-carotene (BC) aiming at the gastrointestinal administration of this lipophilic nutraceutical. The NP were prepared by spontaneous emulsification method using food grade components. Pectin-coated NP have been successfully prepared as confirmed by the increased particle size and negative surface charges due to the pectin’s anionic nature. NP showed spherical shape and monodisperse distribution, with a mean size of 21.3 nm (polydispersity index (PDI) 0.29) for BC PC T80-NP (nanoparticle with β-carotene, pectin and Tween 80) and 261.4 nm (PDI 0.1) for BC PC T20-NP (nanoparticle with β-carotene, pectin and Tween 20). BC was encapsulated at amounts of 530 and 324 µg/ml for BC PC T80-NP and BC PC T20-NP, respectively, with high encapsulation efficiency (> 95%), increasing its antioxidant capacity in vitro, besides no cytotoxic effect. However, only BC PC T20-NP was stable over a 90 days storage period (4°C) and revealed a strong interaction between pectin and mucin. These results suggest that pectin-coated BC PC T20-NP is a promising strategy to improve the bioavailability and permeation of BC for administration through mucosal surfaces
Disciplinas: Química
Palabras clave: Química farmacéutica,
Bagazo de yuca,
Pectina,
Nanopartículas,
Beta-caroteno,
Mucoadhesivos,
Manihot esculenta
Keyword: Medicinal chemistry,
Cassava bagasse,
Pectin,
Nanoparticles,
Beta-carotene,
Mucoadhesives,
Manihot esculenta
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