| Journal: | Anais da Academia Brasileira de Ciencias |
| Database: | PERIÓDICA |
| System number: | 000435813 |
| ISSN: | 0001-3765 |
| Authors: | Silva-Júnior, Joel A. da1 Silva, Amanda C.V.F. da1 Figueiredo, Letícia S1 Araujo, Thiago R2 Freitas, Israelle N2 Carneiro, Everardo M2 Ribeiro, Elane S1 Ribeiro, Rosane A1 |
| Institutions: | 1Universidade Federal do Rio de Janeiro, Laboratorio de Fisiopatologia, Macae, Rio de Janeiro. Brasil 2Universidade Estadual de Campinas, Instituto de Biologia, Campinas, Sao Paulo. Brasil 3Universidade Estadual de Ponta Grossa, Departamento de Biologia Geral, Ponta Grossa, Parana. Brasil |
| Year: | 2020 |
| Volumen: | 92 |
| Number: | 4 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | D-pinitol is one of the major inositol found in plants and studies suggest its potential hypoglycemic and hypolipidemic actions in diabetic rodents. Here, we investigated the actions of D-pinitol on adiposity, and in lipid and glycemic homeostasis in monosodium glutamate (MSG)-obese mice. Swiss mice received daily subcutaneous injections of MSG [(4g/kg of body weight (BW)] or saline [1.25g/kg BW; control (CTL)] during their first five days of life. From 90-120 day-old, half of the MSG and CTL groups received 50 mg D-pinitol/kg BW/day (MPIN and CPIN groups) or vehicle (saline; MSG and CTL groups) by gavage. MSG mice displayed higher abdominal adiposity and hepatic triglycerides (TG) deposition, and increased hepatic expression of lipogenic genes (SREBP-1c, ACC-1 and FASN), but downregulation in AMPKα mRNA. MSG mice also exhibited hyperinsulinemia, islet hypersecretion and hypertrophy, glucose intolerance and insulin resistance. D-pinitol did not change adiposity, glucose intolerance, insulin resistance, but increased hepatic triglycerides (TG) content in MPIN mice, which was associated with increases in gene expressions of SREBP-1c and FASN, but reduction in AMPKα. Furthermore, D-pinitol enhanced insulin secretion in MPIN and CPIN groups. Therefore, D-pinitol enhanced glucose-induced insulin secretion, which may account to enhances hepatic lipogenesis and TG deposition in MPIN mice |
| Disciplines: | Medicina |
| Keyword: | Medicina experimental, Farmacología, Metabolismo y nutrición, Obesidad, Metabolismo lipídico, Función hepática, Insulina, Inositol, D-pinitol, Ratones |
| Keyword: | Experimental medicine, Pharmacology, Metabolism and nutrition, Inositol, Lipid metabolism, Liver function, Obesity, Insulin, D-pinitol, Mice |
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