CYP2B6 516 G>T polymorphism and side effects of the central nervous system in HIV-positive individuals under Efavirenz treatment: Study of a sample from southern Brazil
Document title: CYP2B6 516 G>T polymorphism and side effects of the central nervous system in HIV-positive individuals under Efavirenz treatment: Study of a sample from southern Brazil
Journal: Anais da Academia Brasileira de Ciencias
Database: PERIÓDICA
System number: 000408928
ISSN: 0001-3765
Authors: 1
2
3
3
2
Institutions: 1Universidade Federal de Santa Maria, Departamento de Bioquimica e Biologia Molecular, Santa Maria, Rio Grande do Sul. Brasil
2Universidade Federal do Rio Grande do Sul, Departamento de Genetica, Porto Alegre, Rio Grande do Sul. Brasil
3Universidade de Santa Cruz do Sul, Programa de Pos-Graduacao em Promocao da Saude, Santa Cruz do Sul, Rio Grande do Sul. Brasil
Year:
Season: May
Volumen: 89
Pages: 497-504
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Caso clínico
English abstract This study aimed to identify the 516 G>T polymorphism of the CYP2B6 gene and evaluate its influence on central nervous system (CNS) side effect development in HIV-positive individuals undergoing Efavirenz (EFV) treatment in a population from southern Brazil. Additionally, we performed a survey on the clinical and epidemiological characteristics of our sample. In addition to medical records evaluation, whole blood of 89 individuals was analyzed for viral load, T lymphocyte count (CD4+ and CD8+), and the polymorphism. Considering the side effects of the CNS reported by individuals but without considering the genetic variables, no statistically significant association was noted between the adverse effects and the antiretroviral treatment (including or not EFV). In addition, no statistically significant difference was noted for the influence of genotype on the viral load or the number of T lymphocytes (CD4+ and CD8+) among individuals undergoing EFV treatment. This is the first study that investigated the impact of the 516 G>T polymorphism of the CYP2B6 gene among HIV-positive individuals from southern Brazil. Its clinical significance indicates the need for prospective studies in this population
Disciplines: Medicina
Keyword: Neurología,
Terapéutica y rehabilitación,
Genética,
VIH,
Efavirenz,
Terapia antirretroviral
Keyword: Medicine,
Neurology,
Therapeutics and rehabilitation,
Genetics,
HIV,
Efavirenz,
Antiretroviral therapy
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