CYP2B6 516 G>T polymorphism and side effects of the central nervous system in HIV-positive individuals under Efavirenz treatment: Study of a sample from southern Brazil
Título del documento: CYP2B6 516 G>T polymorphism and side effects of the central nervous system in HIV-positive individuals under Efavirenz treatment: Study of a sample from southern Brazil
Revista: Anais da Academia Brasileira de Ciencias
Base de datos: PERIÓDICA
Número de sistema: 000408928
ISSN: 0001-3765
Autores: 1
2
3
3
2
Instituciones: 1Universidade Federal de Santa Maria, Departamento de Bioquimica e Biologia Molecular, Santa Maria, Rio Grande do Sul. Brasil
2Universidade Federal do Rio Grande do Sul, Departamento de Genetica, Porto Alegre, Rio Grande do Sul. Brasil
3Universidade de Santa Cruz do Sul, Programa de Pos-Graduacao em Promocao da Saude, Santa Cruz do Sul, Rio Grande do Sul. Brasil
Año:
Periodo: May
Volumen: 89
Paginación: 497-504
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Caso clínico
Resumen en inglés This study aimed to identify the 516 G>T polymorphism of the CYP2B6 gene and evaluate its influence on central nervous system (CNS) side effect development in HIV-positive individuals undergoing Efavirenz (EFV) treatment in a population from southern Brazil. Additionally, we performed a survey on the clinical and epidemiological characteristics of our sample. In addition to medical records evaluation, whole blood of 89 individuals was analyzed for viral load, T lymphocyte count (CD4+ and CD8+), and the polymorphism. Considering the side effects of the CNS reported by individuals but without considering the genetic variables, no statistically significant association was noted between the adverse effects and the antiretroviral treatment (including or not EFV). In addition, no statistically significant difference was noted for the influence of genotype on the viral load or the number of T lymphocytes (CD4+ and CD8+) among individuals undergoing EFV treatment. This is the first study that investigated the impact of the 516 G>T polymorphism of the CYP2B6 gene among HIV-positive individuals from southern Brazil. Its clinical significance indicates the need for prospective studies in this population
Disciplinas: Medicina
Palabras clave: Neurología,
Terapéutica y rehabilitación,
Genética,
VIH,
Efavirenz,
Terapia antirretroviral
Keyword: Medicine,
Neurology,
Therapeutics and rehabilitation,
Genetics,
HIV,
Efavirenz,
Antiretroviral therapy
Texto completo: Texto completo (Ver PDF)