| Journal: | Anais da Academia Brasileira de Ciencias |
| Database: | PERIÓDICA |
| System number: | 000435791 |
| ISSN: | 0001-3765 |
| Authors: | Alves, Melina C.C1 Chaves, Douglas S.A2 Benevenuto, Byanca R2 Farias, Beatriz O. de2 Coelho, Shana M.O1 Ferreira, Thais P3 Pereira, Geraldo A1 Santos, Gabriela C.M. dos1 Moreira, Leandra O1 Freitas, Juliana P. de1 Cid, Yara P2 |
| Institutions: | 1Universidade Federal Rural do Rio de Janeiro, Instituto de Veterinaria, Seropedica, Rio de Janeiro. Brasil 2Universidade Federal Rural do Rio de Janeiro, Instituto de Ciencias Biologicas e da Saude, Seropedica, Rio de Janeiro. Brasil 3Universidade Federal Rural do Rio de Janeiro, Instituto de Quimica, Seropedica, Rio de Janeiro. Brasil |
| Year: | 2020 |
| Volumen: | 92 |
| Number: | 4 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Aplicado, descriptivo |
| English abstract | Periodontal disease is considered the main oral cavity disorder in dogs. Essential oils have the potential for use in the prevention and treatment of oral diseases. The antimicrobial activity of Schinus molle L. essential oil (SMEO) has already been reported. Chitosan, a natural product with antimicrobial activity and good biocompatibility has potential in biodental applications. In this study, we evaluated the in vitro antimicrobial activity of SMEO against bacteria associated with periodontal disease in dogs, developed and evaluated the physicochemical properties of a novel chitosan-based buccal delivery system containing SMEO. SMEO showed antimicrobial activity against Gram positive and Gram negative bacteria associated with canine periodontitis, with MIC values of 750 µg.mL-1 for Staphylococcus spp. and Streptococcus spp, 1000 µg.mL-1 for Corynebacterium spp. and 1250 µg.mL-1 for Pseudomonas spp. All formulations evaluated presented adequate physicochemical properties, good stability, and pH values close to buccal pH (5.0–7.0). Chitosan gel loaded with SMEO showed potential as a SMEO delivery system, having the ideal physicochemical and rheological properties (pseudoplastic and apparent viscosities) required for application on buccal tissue. Thus, we can conclude that formulation has the potential to be used for buccal mucosa delivery in the prevention and treatment of periodontal disease in dogs |
| Disciplines: | Medicina veterinaria y zootecnia |
| Keyword: | Pequeñas especies, Medicina veterinaria, Perros, Periodontitis, Gel mucoadhesivo, Aceites esenciales, Schinus molle |
| Keyword: | Companion animals, Veterinary medicine, Dogs, Essential oils, Mcoadhesive gel, Periodontitis, Schinus molle |
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