| Journal: | Anais da Academia Brasileira de Ciencias |
| Database: | PERIÓDICA |
| System number: | 000436191 |
| ISSN: | 0001-3765 |
| Authors: | Schneider, Adriele C.A1 Batisti, Ana P1 Turnes, Bruna L4 Martins, Thiago C4 Lisboa, Maria E.M3 Custódio, Kaue M5 Zanco, Jasper2 Wilson, Karen S.C1 Heymanns, Ana Caroline1 Kanis, Luiz A1 Magnago, Rachel F6 Martins, Daniel F1 Piovezan, Anna P1 |
| Institutions: | 1Universidade do Sul de Santa Catarina, Programa de Pos-graduacao em Ciencias da Saude, Palhoca, Santa Catarina. Brasil 2Universidade do Sul de Santa Catarina, Palhoca, Santa Catarina. Brasil 3Universidade do Sul de Santa Catarina, Laboratorio de Neurociencia Experimental, Palhoca, Santa Catarina. Brasil 4Universidade Federal de Santa Catarina, Departamento de Ciencias Fisiologicas, Florianopolis, Santa Catarina. Brasil 5Universidade do Sul de Santa Catarina, Grupo de Pesquisa em Tecnologia Farmaceutica, Tubarao, Santa Catarina. Brasil 6Universidade do Sul de Santa Catarina, Curso de Medicina, Palhoca, Santa Catarina. Brasil |
| Year: | 2020 |
| Volumen: | 92 |
| Number: | 1 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | The therapeutic effects from Citrus reticulata on painful inflammatory ailments are associated to its flavonoids constituent and phytochemical studies with Citrus genus affirm that the peels have important amounts of it. These bioactive compounds have been a considerable therapeutic source and evaluate potential application of the peel extract is significant. This research aims to investigate the influence of ethanolic crude extract from the peels of Citrus reticulata and its possible mechanism of action in different animal models of pain. The extract reduced hyperalgesia in the second phase of formalin test (vehicle: 501.5 ± 40.0 s; C. reticulata extract 300 mg/kg: 161.8 ± 41.1 s), in the carrageenan model (vehicle at 4th h: 82.5 ± 9.6 %; C. reticulata extract 300 mg/kg at 4th h: 47.5 ± 6.5 %) and in Complete Freund’s Adjuvant model (vehicle: 501.5 ± 40.0 s; C. reticulata extract 300 mg/kg: 161.8 ± 41.1 s). The possible contribution of opioidergic and adenosinergic systems in the anti-hyperalgesic effect of C. reticulata extract was observed after treatment, with non-selective antagonists for both systems, which produced reversal effects. In conclusion, these properties of C. reticulata extract suggest a potential therapeutic benefit in treating painful conditions |
| Disciplines: | Medicina |
| Keyword: | Farmacología, Plantas medicinales, Dolor, Inflamación, Opioides, Adenosina, Citrus reticulata, Rutaceae |
| Keyword: | Pharmacology, Medicinal plants, Pain, Inflammation, Opioids, Adenosine, Citrus reticulata, Rutaceae |
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