| Journal: | Anais brasileiros de dermatologia |
| Database: | |
| System number: | 000558030 |
| ISSN: | 0365-0596 |
| Authors: | Bevilaqua, Mariele1 Rey, Maria Carolina Widholzer3 Cappellini, Gian Carlo Antonini4 Riccardi, Felice5 Fortes, Cristina6 Roehe, Adriana Vial7 Bonamigo, Renan Rangel8 |
| Institutions: | 1Universidade Federal de Ciências da Saúde de Porto Alegre, Department of Dermatology, Porto Alegre, Rio Grande do Sul. Brasil 2Universidade Luterana do Brasil, Canoas, Rio Grande do Sul. Brasil 3Santa Casa de Misericórdia de Porto Alegre, Department of Dermatology, Porto Alegre, Rio Grande do Sul. Brasil 4Hospital Sandro Pertini, Department of Oncology, Rome. Italia 5Santa Casa de Misericórdia de Porto Alegre, Hospital Santa Rita, Porto Alegre, Rio Grande do Sul. Brasil 6Istituto Dermopatico dell'Immacolata, Department of Epidemiology, Rome. Italia 7Universidade Federal de Ciências da Saúde de Porto Alegre, Department of Patology, Porto Alegre, Rio Grande do Sul. Brasil 8Universidade Federal do Rio Grande do Sul, Department of Dermatology, Porto Alegre, Rio Grande do Sul. Brasil |
| Year: | 2023 |
| Volumen: | 98 |
| Number: | 6 |
| Pages: | 793-798 |
| Country: | Brasil |
| Language: | Inglés |
| English abstract | Background In cutaneous melanomas in general, tumor inflammatory infiltrate (TII) can protect against distant metastases, but there is no consensus when only thin primary cutaneous melanomas (TPCM) are considered. Objective To investigate the presence of TII in TPCM and the relationship between TII and the occurrence of metastases. Methods Case-control study including 50 patients with TPCM, 22 metastatic (MC group) and 28 non-metastatic (NMC group). The presence of TII was evaluated and, if present, qualified as mild, moderate or marked. Results The mean age was 50.7 years in the MC and 56.2 years in the NMC group (p = 0.234), and the male sex predominated in the MC group (63.6%). The average Breslow thickness was higher in the MC when compared to that observed in the NMC (respectively 0.8 vs. 0.6 mm, p = 0.012). The presence of ulceration occurred in 22.7% of the MC and 17.9% of the NMC (p = 0.732). TII was present in all 50 TPCM, being marked or moderate in 67.9% of the NMC and 54.5% in the MC group (p = 0.503). In the multivariate analysis, the presence of moderate and marked TII had an Odds Ratio (OR) of 0.57 (95% Confidence Interval CI: 0.18‒1.8) and adjusted OR of 0.68 (95% CI 0.13‒3.99). Study limitations Small sample size. Conclusions TII was present in all TPCM (with and without metastases), and it was not possible to demonstrate a protective effect of TII against the appearance of metastases. |
| Keyword: | Biomarkers, Lymphocytes, tumor-infiltrating, Melanoma, Neoplasm metastasis, Prognosis |
| Full text: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
