| Revista: | Anais brasileiros de dermatologia |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000460403 |
| ISSN: | 0365-0596 |
| Autores: | Bevilaqua, Mariele1 Rey, Maria Carolina Widholzer3 Cappellini, Gian Carlo Antonini4 Riccardi, Felice5 Fortes, Cristina6 Roehe, Adriana Vial7 Bonamigo, Renan Rangel8 |
| Instituciones: | 1Universidade Federal de Ciencias da Saude de Porto Alegre, Departamento de Dermatologia, Porto Alegre, Rio Grande do Sul. Brasil 2Santa Casa de Misericordia de Porto Alegre, Departamento de Dermatologia, Porto Alegre, Rio Grande do Sul. Brasil 3Ospedale Sandro Pertini, Diepartimento di Oncologia, Roma, Lazio. Italia 4Santa Casa de Misericórdia de Porto Alegre, Hospital Santa Rita, Porto Alegre, Rio Grande do Sul. Brasil 5Istituto Dermopatico dell'Immacolata, Department of Epidemiologia, Roma, Lazio. Italia 6Universidade Federal de Ciencias da Saude de Porto Alegre, Departamento de Patologia, Porto Alegre, Rio Grande do Sul. Brasil 7Universidade Federal do Rio Grande do Sul, Departamento de Dermatologia, Porto Alegre, Rio Grande do Sul. Brasil |
| Año: | 2023 |
| Volumen: | 98 |
| Número: | 6 |
| Paginación: | 793-798 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Background In cutaneous melanomas in general, tumor inflammatory infiltrate (TII) can protect against distant metastases, but there is no consensus when only thin primary cutaneous melanomas (TPCM) are considered. Objective To investigate the presence of TII in TPCM and the relationship between TII and the occurrence of metastases. Methods Case-control study including 50 patients with TPCM, 22 metastatic (MC group) and 28 non-metastatic (NMC group). The presence of TII was evaluated and, if present, qualified as mild, moderate or marked. Results The mean age was 50.7 years in the MC and 56.2 years in the NMC group (p = 0.234), and the male sex predominated in the MC group (63.6%). The average Breslow thickness was higher in the MC when compared to that observed in the NMC (respectively 0.8 vs. 0.6 mm, p = 0.012). The presence of ulceration occurred in 22.7% of the MC and 17.9% of the NMC (p = 0.732). TII was present in all 50 TPCM, being marked or moderate in 67.9% of the NMC and 54.5% in the MC group (p = 0.503). In the multivariate analysis, the presence of moderate and marked TII had an Odds Ratio (OR) of 0.57 (95% Confidence Interval [CI]: 0.18‒1.8) and adjusted OR of 0.68 (95% CI 0.13‒3.99). Study limitations Small sample size. Conclusions TII was present in all TPCM (with and without metastases), and it was not possible to demonstrate a protective effect of TII against the appearance of metastases |
| Disciplinas: | Medicina |
| Palabras clave: | Dermatología, Oncología, Melanoma, Infiltración tumoral, Linfocitos, Biomarcadores, Metástasis, Prognosis |
| Keyword: | Dermatology, Oncology, Melanoma, Tumor infiltration, Lymphocytes, Biomarkers, Metastasis, Prognosis |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
