Journal: | Anais brasileiros de dermatologia |
Database: | |
System number: | 000558010 |
ISSN: | 0365-0596 |
Authors: | Schlenker, Sofia Makishi1 Munhoz, Sofia Inez1 Busanello, André Rochinski1 Sanches, Matheus Guedes1 Kahlow, Barbara Stadler1 Nisihara, Renato1 Skare, Thelma Larocca1 |
Institutions: | 1Faculdade Evangélica Mackenzie do Paraná, Medicine Course, Curitiba, PR. Brasil 2Hospital Universitário Evangélico Mackenzie, Curitiba, PR. Brasil |
Year: | 2023 |
Volumen: | 98 |
Number: | 6 |
Pages: | 799-805 |
Country: | Brasil |
Language: | Inglés |
English abstract | Background Psoriasis is a protean disease associated with several comorbidities that may have increased levels of adiponectin such as resistin. This may affect the patients atherosclerotic risk. Objective To study resistin levels in a sample of Brazilian patients with psoriasis and its association with clinical profile, comorbidities, and carotid Intima-Media Thickness (cIMT). Methods This is a cross-sectional study of 119 individuals: 34 healthy controls and 85 patients with psoriasis, 42 of which with skin involvement only and 43 with psoriatic arthritis. Clinical and epidemiological data, measurement of PASI (Psoriasis Area Severity Index) and DAPSA (Disease Activity in Psoriatic Arthritis), lipid profile, cIMT by ultrasound were collected from medical records. Resistin serum levels were measured by ELISA. Results Patients with psoriasis had higher resistin levels (p = 0.009) and worse cIMT (p = 0.0002) than controls. In the psoriasis sample, no associations of resistin levels with epidemiological, clinical findings, and activity indexes were found. Resistin serum levels were associated with the presence of diabetes (p = 0.008) and metabolic syndrome (p = 0.01) and correlated with total cholesterol (r = 0.26) and triglycerides (r = 0.33) but not with cIMT. Study limitations This work is limited by its transversal design and by the limited number of patients included. Conclusion Resistin serum levels are elevated in psoriasis patients. In this sample, clinical, epidemiological, and activity indexes were not linked to resistin serum levels, but atherosclerotic risk factors were. |
Keyword: | Atherosclerosis, Arthritis, Psoriatic, Psoriasis, Resistin |
Full text: | Texto completo (Ver HTML) Texto completo (Ver PDF) |