| Revista: | Anais brasileiros de dermatologia |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000401637 |
| ISSN: | 0365-0596 |
| Autores: | Farshchian, Mahmoud1 Ansar, Akram1 Sobhan, Mohammadreza1 Hoseinpoor, Valiollah1 |
| Instituciones: | 1Hamadan University of Medical Sciences, Hamadan. Irán |
| Año: | 2016 |
| Periodo: | Sep-Oct |
| Volumen: | 91 |
| Número: | 5 |
| Paginación: | 580-583 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Aplicado |
| Resumen en inglés | C-reactive protein is an inflammatory biomarker and its level increases in the serum of psoriatic patients. Its level is also associated with Psoriasis Area and Severity Index score. Objective: The aim of this study was to assess the decrement of serum C-reactive protein level with narrow-band ultraviolet B (NB-UVB) therapy. Methods: C-reactive protein serum levels in psoriasis patients were measured before and after treatment with NB-UVB and the data were analyzed in relation to the Psoriasis Area and Severity Index score improvement. Results: Baseline C-reactive protein levels among psoriatic patients were higher than normal. These levels decreased significantly after treatment (P<0.001). At the beginning of the study, patients with higher levels of C-reactive protein also had more extensive and severe skin involvement. The highest decrease in C-reactive protein was observed in patients who responded better to the treatment and achieved a higher Psoriasis Area and Severity Index 75%. There was an association between baseline Psoriasis Area and Severity Index scores and C-reactive protein levels. Conclusion: Patients with moderate to severe plaque-type psoriasis had active systemic inflammation, which was demonstrated by increased levels of C-reactive protein. Furthermore, skin disease severity was correlated with C-reactive protein levels. Phototherapy healed the psoriatic skin lesions and reduced inflammation, while decreasing C-reactive protein levels |
| Disciplinas: | Medicina |
| Palabras clave: | Dermatología, Terapéutica y rehabilitación, Inmunología, Proteína C reactiva, Psoriasis, Rayos ultravioleta, Fototerapia |
| Keyword: | Medicine, Dermatology, Therapeutics and rehabilitation, Immunology, C reactive protein, Psoriasis, Ultraviolet rays, Phototherapy |
| Texto completo: | Texto completo (Ver HTML) |
