| Journal: | Acta scientiarum. Agronomy |
| Database: | PERIÓDICA |
| System number: | 000459912 |
| ISSN: | 1679-9275 |
| Authors: | Sant’Anna, Isabela de Castro1 Silva, Gabi Nunes2 Nascimento, Moysés1 Cruz, Cosme Damião1 |
| Institutions: | 1Universidade Federal de Vicosa, Laboratorio de Bioinformatica, Vicosa, Minas Gerais. Brasil 2Universidade Federal de Rondonia, Departamento de Matematica e Estatistica, Ji-Parana, Rondonia. Brasil |
| Year: | 2021 |
| Volumen: | 43 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, analítico |
| English abstract | This paper aimed to evaluate the effectiveness of subset selection of markers for genome-enabled prediction of genetic values using radial basis function neural networks (RBFNN). To this end, an F1 population derived from the hybridization of divergent parents with 500 individuals genotyped with 1000 SNP-type markers was simulated. Phenotypic traits were determined by adopting three different gene action models - additive, additive-dominant, and epistatic, representing two dominance situations: partial and complete with quantitative traits having a heritability (h2) of 30 and 60%; traits were controlled by 50 loci, considering two alleles per locus. Twelve different scenarios were represented in the simulation. The stepwise regression was used before the prediction methods. The reliability and the root mean square error were used for estimation using a fivefold cross-validation scheme. Overall, dimensionality reduction improved the reliability values for all scenarios, specifically with h2 =30 the reliability value from 0.03 to 0.59 using RBFNN and from 0.10 to 0.57 with RR-BLUP in the scenario with additive effects. In the additive dominant scenario, the reliability values changed from 0.12 to 0.59 using RBFNN and from 0.12 to 0.58 with RR-BLUP, and in the epistasis scenarios, the reliability values changed from 0.07 to 0.50 using RBFNN and from 0.06 to 0.47 with RR-BLUP. The results showed that the use of stepwise regression before the use of these techniques led to an improvement in the accuracy of prediction of the genetic value and, mainly, to a large reduction of the root mean square error in addition to facilitating processing and analysis time due to a reduction in dimensionality |
| Disciplines: | Biología |
| Keyword: | Genética, Redes neuronales, Regresión stepwise, Genoma |
| Keyword: | Genetics, Neural networks, Genome, Stepwise regression |
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