| Journal: | Acta gastroenterológica latinoamericana |
| Database: | PERIÓDICA |
| System number: | 000358468 |
| ISSN: | 0300-9033 |
| Authors: | Andrade, Danilo Leite1 Oliveira, Maria de Fatima Paim de1 Souza, Teodoro Felipe Pereira de1 Lima, Rafaela Araujo1 Bomfim, Ednaldo Andrade1 Rego, Vitoria Regina Pedreira de Almeida1 Parana, Raymundo1 Schinoni, Maria Isabel1 |
| Institutions: | 1Universidade Federal da Bahia, Salvador, Bahia. Brasil |
| Year: | 2012 |
| Season: | Dic |
| Volumen: | 42 |
| Number: | 4 |
| Pages: | 285-290 |
| Country: | Argentina |
| Language: | Español |
| Document type: | Estadística o encuesta |
| Approach: | Descriptivo |
| Spanish abstract | METAVIR F3/F4 en 66,7% de los pacientes. Conclusiones. Este estudio mostró una prevalencia mayor de HCV en pacientes con psoriasis que en la población general. Fueron encontradas lesiones dermatológicas más graves en los portadores de HCV |
| English abstract | Introduction. Hepatitis C is the major cause ofliver transplantation and hepatocellular carcinoma and shows a global prevalence of 3%. Hepatitis C virus (HCV) is associated with extrahepatic manifestations (e.g., cutaneous affections) and psoriasis has been reported as a comorbidity. However, there are few studies analyzing this association. Objectives. 1) To evaluateanti-HCV prevalence (confirmed by the detection of HCV-RNA) in patients with psoriasis and its potential clinical implications; 2) to analyze the prevalence of otherinfections in this population: hepatitis B virus (HBV), human T lymphotropic virus, subtypes I and II (HTLV I/II), and human immunodeficiency virus, subtypes I and II (HIV I/II). Methods. This is cross sectional study that included patients older than 18 years-old with psoriasis from a Teaching Hospital in Salvador, Bahia. An epidemiological questionnaire was administered and serological tests were performed: surface HBV antigen (HBsAg), antibodies to HBsAg (anti-HBs), anti-HTLV I/II, anti-HIV I/II, and antiHCV. Anti-HCV positive results were confirmed by HCV-RNA detection and viral genotype was determined. Skin lesions were evaluated using the Psoriasis Area and Severity Index (PASI). Liver biopsies were analyzed according to the METAVIR score. Results. From the 140 patients included in the study, 7.1% were anti-HCV positive confirmed by the detection of HCV RNA. This prevalence was higher than that inthe city of Salvador(1.5%).Other serological results were: HBsAg 0%, anti-HBs 25.8%, HTLV I/II (0,9%), and HIV I/II 0%. PASI score was higher in positive anti-HCV patients than in their negative counterparts (19.5 versus 13.4). Histopathological analysis showed 66.7% of patients with METAVIR F3/F4. Conclusion. Anti-HCV prevalencewas higher in psoriasis patients than in the general population of the city. More severe skin lesions were found in HCV patients |
| Disciplines: | Medicina |
| Keyword: | Dermatología, Gastroenterología, Psoriasis, Hepatitis C, Epidemiología |
| Keyword: | Medicine, Dermatology, Gastroenterology, Psoriasis, Hepatitis C, Epidemiology |
| Full text: | Texto completo (Ver PDF) |
